Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.13/2197
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degois.publication.firstPage329pt_PT
degois.publication.lastPage336pt_PT
degois.publication.titleMetabolic Syndrome and Related Disorderspt_PT
dc.contributor.authorSilventoinen, Karri-
dc.contributor.authorGouveia, Élvio-
dc.contributor.authorJelenkovic, Aline-
dc.contributor.authorMaia, José-
dc.contributor.authorAntunes, António M.-
dc.contributor.authorCarvalho, Miguel A A Pinheiro de-
dc.contributor.authorBrehm, António M-
dc.contributor.authorThomis, Martine-
dc.contributor.authorLefevre, Johan-
dc.contributor.authorKaprio, Jaakko-
dc.contributor.authorFreitas, Duarte-
dc.date.accessioned2018-12-12T10:15:43Z-
dc.date.available2018-12-12T10:15:43Z-
dc.date.issued2017-
dc.identifier.citationSilventoinen K., Gouveia, E.R., Jelenkovic, A., Maia, J.A., Antunes A.M., Carvalho, M.A., Brehm, A.M., Thomis, M., Lefevre, J., Jaakko Kaprio, J., Freitas, D.F. (2017). The genetic background of clustering of metabolic traits in children and adolescents. Metabolic Syndrome and Related Disorders. 15(7):329-336.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2197-
dc.description.abstractBackground: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence. Data and Methods: Nine metabolic traits were measured in 214 complete twin pairs aged 3–18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008. The variation of and covariations between the traits were decomposed into genetic and environmental components by using classical genetic twin modeling. Results: A model, including additive genetic and environmental factors unique for each twin individual, explained the variation of metabolic factors well. Under this model, the heritability estimates varied from 0.47 (systolic blood pressure in children under 12 years of age) to 0.91 (high-density lipoprotein [HDL] cholesterol in adolescents 12 years of age or older). The most systematic correlations were found between adiposity (body mass index and waist circumference) and blood lipids (HDL cholesterol, low-density lipoprotein cholesterol, and triglycerides), as well as blood pressure. These correlations were mainly explained by common genetic factors. Conclusions: Our results suggest that obesity, in particular, is behind the clustering of metabolic factors in children and adolescents. Both general and abdominal obesity partly share the same genetic background as blood lipids and blood pressure. Obesity prevention early in childhood is important in reducing the risk of metabolic diseases in adulthood.pt_PT
dc.language.isoengpt_PT
dc.publisherMary Ann Liebert, Inc.pt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/POCI/56834/PTpt_PT
dc.rightsrestrictedAccesspt_PT
dc.subjectAdipositypt_PT
dc.subjectAdolescentpt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectCardiovascular Diseasespt_PT
dc.subjectChildpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectCholesterol, HDLpt_PT
dc.subjectCholesterol, LDLpt_PT
dc.subjectDiseases in Twinspt_PT
dc.subjectEnvironmentpt_PT
dc.subjectFemalept_PT
dc.subjectGenetic Backgroundpt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMetabolic Syndromept_PT
dc.subjectPortugalpt_PT
dc.subjectSystolept_PT
dc.subjectTwins, Dizygoticpt_PT
dc.subjectTwins, Monozygoticpt_PT
dc.subjectWaist Circumferencept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Sociaispt_PT
dc.titleThe Genetic Background of Metabolic Trait Clusters in Children and Adolescentspt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume15(7)pt_PT
dc.identifier.doi10.1089/met.2017.0013pt_PT
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