Gouveia, MarisolFigueira, JoãoJardim, Manuel G.Castro, RitaTomás, HelenaRissanen, KariRodrigues, João2018-07-312018-07-312018Gouveia, M.; Figueira, J.; Jardim, M.G.; Castro, R.; Tomás, H.; Rissanen, K.; Rodrigues, J. Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells. Molecules 2018, 23, 1471.1420-3049http://hdl.handle.net/10400.13/2069Here and for the first time, we show that the organometallic compound [Ru(η5-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(η5-C5H5)(PPh3)2]+ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(η5-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma celllines(A2780cisRcells). Also,RuCpandthepreparedmetallodendrimersareactiveagainsthuman mesenchymal stem cells (hMSCs), which are often found in the tumor microenvironment where they seem to play a role in tumor progression and drug resistance.engDendrimersNanocarriersMetallodrugsRutheniumPlatinumCisplatinCancer treatmenthMSCsToxicityNanomedicine.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da Madeirajournal article10.3390/molecules23061471