Li, YulinSantos, José LuísMaciel, DinaTomás, HelenaRodrigues, João2019-06-182019-06-182011Li, Y., Santos, J. L., Maciel, D., Tomás, H., & Rodrigues, J. (2011). Injectable hybrid laponite/alginate hydrogels for sustained release of methylene blue. Journal of Controlled Release, 152, e55-e57.0168-3659http://hdl.handle.net/10400.13/2405The incorporation of biocompatible Laponite (LP) into alginate hydrogels greatly increases the drug encapsulation efficiency of methylene blue (MB). By raising the LP content from 0 to 0.5 wt.%, the half-release time (t1/2) of MB in oven-dried gels increases from ~2 h to ~10 h, while t1/2 in vacuum-dried gels slightly changes from ~1 h to ~2 h. Increasing LP content together with drying modes can induce the MB release mechanism froma diffusion-controlled release into a swelling-controlled one.engLaponiteAlginateInjectable hybrid hydrogelsDrug deliveryRelease mechanism.Faculdade de Ciências Exatas e da Engenhariajournal article10.1016/j.jconrel.2011.08.119