Martins, Gonçalo N.Spínola, VítorCastilho, Paula C.2021-03-242021-03-242020Martins, G. N., Spínola, V., & Castilho, P. C. (2020). Release of adsorbed ferulic acid in simulated gastrointestinal conditions. European Food Research and Technology, 246(6), 1297-1306. https://doi.org/10.1007/s00217-020-03489-whttp://hdl.handle.net/10400.13/3194Ferulic acid (FA) is a natural antioxidant with limited absorption when conjugated with biomolecules but whose free form is readily absorbed in the stomach and, to a lesser extent, in the ileum. The latter sufers from infammation and oxidative stress, so a novel strategy for the delivery of FA in this compartment of the gastrointestinal tract was developed. Using the neutral un-functionalized resin Lewatit® VP OC 1064 MD PH, under optimized conditions, a loading of 144 mg FA/g of dry resin was obtained. By means of an in vitro simulated digestion, an average release of 32 mg FA/g of dry loaded resin (recovery of 22%) was observed in intestinal conditions. The incorporation/release of FA onto/from the resin was confrmed by ATR-FTIR spectroscopy and by HPLC-DAD. This work showed that the free form of FA can efectively be delivered in the small intestine, after immobilization in solid matrices.engFerulic acidAdsorptionReleaseIn vitro digestion simulationIntestine.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da Madeirajournal article10.1007/s00217-020-03489-w