Su, XiqiWang, LeXie, JingHuaLiu, XiaoHuiTomás, Helena2022-06-172022-06-172021Su, X., Wang, L., Xie, J., Liu, X., & Tomás, H. (2021). Cyclotriphosphazene-based derivatives for antibacterial applications: an update on recent advances. Current Organic Chemistry, 25(2), 301-314.http://hdl.handle.net/10400.13/4331As a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used for the synthesis of varieties of derivatives, including metal-binding complexes and several unique organometallic compounds, which exhibit potential catalytic, flame retardant and bio logical activities. Some metal-binding HCCP derivatives have shown antibacterial activities as free ligands and metal complexes. These derivatives can also serve as building blocks for the formation of antibacterial metal-containing polymers. This mini-review is focused on the de sign and development of HCCP derivatives as potential antibacterial agents with representa tive examples as well as antibacterial mechanisms from recent yearsengHexachlorocyclotriphosphazene(HCCP)AntibacterialAntibacterial mechanismMetalLigandPolymer.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da Madeirajournal article10.2174/1385272824999201001154127