Wang, ZhaoOlim, FilipeSun, JingjingNeves, Ana RuteMendes, FátimaTomás, HelenaSheng, Ruilong2021-11-162021-11-162021Wang, Z., Olim, F., Sun, J., Neves, A. R., Mendes, F., Tomás, H., & Sheng, R. Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy. Medicine Research. DOI: 10.21127/yaoyimr20200023http://hdl.handle.net/10400.13/3821Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.engPolymersDoxorubicinProdrugStimuli-responsiveDrug deliveryNanosystem.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da Madeirajournal article10.21127/yaoyimr20200023