Olim, FilipeNeves, Ana RuteWang, ZhaoSun, JingjingTomás, HelenaSheng, Ruilong2021-11-162021-11-162020Olim, F., Neves, A. R., Wang, Z., Sun, J., Tomás, H., & Sheng, R. (2020). Prodrug Systems (I): Lipid-based Doxorubicin Prodrugs and their nanodelivery systems. Medicine Research, 4(1-2), 200013. DOI: 10.21127/yaoyimr20200013http://hdl.handle.net/10400.13/3820Using natural lipids to covalently connect with antitumor agents to construct lipid-based molecular prodrugs and their nanosystems is a promising research frontier for sustainable medicinal chemistry, nanobiotechnology and tumor chemotherapy. This paper reviewed recent progress of lipid-based doxorubicin (molecular) prodrugs and their nanodelivery systems, including lipid-doxorubicin prodrugs, stimuli-responsive lipid-doxorubicin prodrugs, and lipid-doxorubicin prodrug-based drug co-delivery nanosystems. Additionally, possible future research outlooks in this field were also discussed.engLipidDoxorubicinProdrugsStimuli-responsiveDrug co-deliveryNanosystems.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da Madeirajournal article10.21127/yaoyimr20200013