Mignani, SergeRodrigues, JoãoRoy, RenéShi, XiangyangCeña, ValentinEl Kazzouli, SaïdMajoral, Jean-Pierre2019-06-282019-06-282019Mignani, S., Rodrigues, J., Roy, R., Shi, X., Ceña, V., El Kazzouli, S., & Majoral, J. P. (2019). Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: key factor analysis (Part 1). Drug discovery today.1359-6446http://hdl.handle.net/10400.13/2444Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary to designate and develop 'safe' dendrimers, which is currently a crucial concern. Here, we analyze the key in vitro physicochemical parameters to be considered for preclinical evaluation of biomedical dendrimers.engBiomedical dendrimerDendrimersPhysicochemical parameters.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da Madeirajournal article10.1016/j.drudis.2019.02.014