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Genetic regulation of body size and morphology in children: a twin study of 22 anthropometric traits

2023Journal article Open access
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dc.contributor.authorSilventoinen, Karri
dc.contributor.authorMaia, José
dc.contributor.authorLi, Weilong
dc.contributor.authorSund, Reijo
dc.contributor.authorGouveia, Élvio R.
dc.contributor.authorAntunes, António
dc.contributor.authorMarques, Gonçalo
dc.contributor.authorThomis, Martine
dc.contributor.authorJelenkovic, Aline
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorFreitas, Duarte Luís de
dc.date.accessioned2023-07-17T11:16:47Z
dc.date.available2023-07-17T11:16:47Z
dc.date.issued2023
dc.description.abstractAnthropometric measures show high heritability, and genetic correlations have been found between obesity related traits. However, we lack a comprehensive analysis of the genetic background of human body morphology using detailed anthropometric measures. METHODS: Height, weight, 7 skinfold thicknesses, 7 body circumferences and 4 body diameters (skeletal breaths) were measured in 214 pairs of twin children aged 3–18 years (87 monozygotic pairs) in the Autonomous Region of Madeira, Portugal. Factor analysis (Varimax rotation) was used to analyze the underlying structure of body physique. Genetic twin modeling was used to estimate genetic and environmental contributions to the variation and co-variation of the anthropometric traits. RESULTS: Together, two factors explained 80% of the variation of all 22 anthropometric traits in boys and 73% in girls. Obesity measures (body mass index, skinfold thickness measures, as well as waist and hip circumferences) and limb circumferences loaded most strongly on the first factor, whereas height and body diameters loaded especially on the second factor. These factors as well as all anthropometric measures showed high heritability (80% or more for most of the traits), whereas the rest of the variation was explained by environmental factors not shared by co-twins. Obesity measures showed high genetic correlations (0.75–0.98). Height showed the highest genetic correlations with body diameter measures (0.58–0.76). Correlations between environmental factors not shared by co-twins were weaker than the genetic correlations but still substantial. The correlation patterns were roughly similar in boys and girls. CONCLUSIONS: Our results show high genetic correlations underlying the human body physique, suggesting that there are sets of genes widely affecting anthropometric traits. Better knowledge of these genetic variants can help to understand the development of obesity and other features of the human physique.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilventoinen, K., Maia, J., Li, W., Sund, R., Gouveia, É. R., Antunes, A., ... & Freitas, D. (2023). Genetic regulation of body size and morphology in children: a twin study of 22 anthropometric traits. International Journal of Obesity, 47(3), 181-189.pt_PT
dc.identifier.doi10.1038/s41366-023-01253-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5281
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnatomypt_PT
dc.subjectGeneticspt_PT
dc.subjectBody sizept_PT
dc.subjectTwin studypt_PT
dc.subjectChildrenpt_PT
dc.subjectObesitypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Sociaispt_PT
dc.titleGenetic regulation of body size and morphology in children: a twin study of 22 anthropometric traitspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FDES%2F56834%2F2004/PT
oaire.citation.endPage189pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage181pt_PT
oaire.citation.titleInternational Journal of Obesitypt_PT
oaire.citation.volume47pt_PT
oaire.fundingStreamPOCI
person.familyNameSilventoinen
person.familyNameMaia
person.familyNameSund
person.familyNameGouveia
person.familyNameAntunes
person.familyNameThomis
person.familyNameKaprio
person.familyNameFreitas
person.givenNameKarri
person.givenNameJosé
person.givenNameReijo
person.givenNameÉlvio Rúbio
person.givenNameAntónio Manuel
person.givenNameMartine
person.givenNameJaakko
person.givenNameDuarte
person.identifier.ciencia-id3B10-8BDF-0D67
person.identifier.ciencia-id7C1E-A4CD-64EA
person.identifier.ciencia-idAA13-1821-A447
person.identifier.orcid0000-0003-1759-3079
person.identifier.orcid0000-0002-3273-0046
person.identifier.orcid0000-0002-6268-8117
person.identifier.orcid0000-0003-0927-692X
person.identifier.orcid0000-0002-7532-3053
person.identifier.orcid0000-0001-9093-2191
person.identifier.orcid0000-0002-3716-2455
person.identifier.orcid0000-0001-6642-3370
person.identifier.ridN-5471-2016
person.identifier.scopus-author-id7006248142
person.identifier.scopus-author-id7004598232
person.identifier.scopus-author-id35379599600
person.identifier.scopus-author-id37096975400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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