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Principal physicochemical methods used to characterize dendrimer molecule complexes used as genetic therapy agents, nanovaccines or drug carriers

2017Journal article Restricted access
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dc.contributor.authorRolando Alberto, Rodriguez Fonseca
dc.contributor.authorRodrigues, João
dc.contributor.authorMuñoz-Fernández, María de los Angeles
dc.contributor.authorMartínez Muñoz, Alberto
dc.contributor.authorFragoso Vázquez, Manuel Jonathan
dc.contributor.authorCorrea-Basurto, José
dc.date.accessioned2019-06-27T09:00:58Z
dc.date.available2019-06-27T09:00:58Z
dc.date.issued2017
dc.description.abstractNanomedicine is the application of nanotechnology to medicine. This field is related to the study of nanodevices and nanomaterials applied to various medical uses, such as in improving the pharmacological properties of different molecules. Dendrimers are synthetic nanoparticles whose physicochemical properties vary according to their chemical structure. These molecules have been extensively investigated as drug nanocarriers to improve drug solubility and as sustained-release systems. New therapies such as gene therapy and the development of nanovaccines can be improved by the use of dendrimers. The biophysical and physicochemical characterization of nucleic acid/peptide-dendrimer complexes is crucial to identify their functional properties prior to biological evaluation. In that sense, it is necessary to first identify whether the peptide-dendrimer or nucleic aciddendrimer complexes can be formed and whether the complex can dissociate under the appropriate conditions at the target cells. In addition, biophysical and physicochemical characterization is required to determine how long the complexes remain stable, what proportion of peptide or nucleic acid is required to form the complex or saturate the dendrimer, and the size of the complex formed. In this review, we present the latest information on characterization systems for dendrimer-nucleic acid, dendrimer-peptide and dendrimer-drug complexes with several biotechnological and pharmacological applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodríguez, F. R. A.; Rodrigues, J.; Muñoz-Fernández, M. A.; Martínez, M. A.; Fragoso, V. M. J.; Correa B. J. Principal Physicochemical Methods Used to Characterize Dendrimer Molecule Complexes Used as Genetic Therapy Agents, Nanovaccines or Drug Carriers. Curr. Pharm. Des. 2017, 23, 1-8.pt_PT
dc.identifier.doi10.2174/1381612823666170220164535pt_PT
dc.identifier.issn1381-6128
dc.identifier.urihttp://hdl.handle.net/10400.13/2432
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relationMadeira Chemistry Research Centre
dc.subjectNanovaccinespt_PT
dc.subjectGene therapypt_PT
dc.subjectDendrimerspt_PT
dc.subjectPeptidespt_PT
dc.subjectNucleic acidspt_PT
dc.subjectFunctional properties characterizationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titlePrincipal physicochemical methods used to characterize dendrimer molecule complexes used as genetic therapy agents, nanovaccines or drug carrierspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00674%2F2013/PT
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleCurrent Pharmaceutical Designpt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRodrigues
person.familyNameMuñoz-Fernández
person.givenNameJoão
person.givenNameMª Ángeles
person.identifier548431
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id361C-ABDD-87F4
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-0813-4500
person.identifier.ridB-6816-2008
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id25931106800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication53031fca-b2e7-4ce4-bda9-61e486da4547
relation.isAuthorOfPublication4d8ae1df-d617-4547-985e-4276a1fefeee
relation.isAuthorOfPublication.latestForDiscovery4d8ae1df-d617-4547-985e-4276a1fefeee
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