Utilize este identificador para referenciar este registo:
|Título:||The Genetic Background of Metabolic Trait Clusters in Children and Adolescents|
Antunes, António M.
Carvalho, Miguel A A Pinheiro de
Brehm, António M
Body Mass Index
Diseases in Twins
Faculdade de Ciências Sociais
|Editora:||Mary Ann Liebert, Inc.|
|Citação:||Silventoinen K., Gouveia, E.R., Jelenkovic, A., Maia, J.A., Antunes A.M., Carvalho, M.A., Brehm, A.M., Thomis, M., Lefevre, J., Jaakko Kaprio, J., Freitas, D.F. (2017). The genetic background of clustering of metabolic traits in children and adolescents. Metabolic Syndrome and Related Disorders. 15(7):329-336.|
|Resumo:||Background: It is well known that metabolic risk factors of cardiovascular diseases are correlated, but the background of this clustering in children is more poorly known than in adults. Thus, we studied the contribution of genetic and environmental factors to the clustering of metabolic traits in childhood and adolescence. Data and Methods: Nine metabolic traits were measured in 214 complete twin pairs aged 3–18 years in the Autonomous Region of Madeira, Portugal, in 2007 and 2008. The variation of and covariations between the traits were decomposed into genetic and environmental components by using classical genetic twin modeling. Results: A model, including additive genetic and environmental factors unique for each twin individual, explained the variation of metabolic factors well. Under this model, the heritability estimates varied from 0.47 (systolic blood pressure in children under 12 years of age) to 0.91 (high-density lipoprotein [HDL] cholesterol in adolescents 12 years of age or older). The most systematic correlations were found between adiposity (body mass index and waist circumference) and blood lipids (HDL cholesterol, low-density lipoprotein cholesterol, and triglycerides), as well as blood pressure. These correlations were mainly explained by common genetic factors. Conclusions: Our results suggest that obesity, in particular, is behind the clustering of metabolic factors in children and adolescents. Both general and abdominal obesity partly share the same genetic background as blood lipids and blood pressure. Obesity prevention early in childhood is important in reducing the risk of metabolic diseases in adulthood.|
|Aparece nas colecções:||Artigos em revistas internacionais|
Ficheiros deste registo:
|The Genetic Background of Metabolic Trait Clusters.pdf||98,99 kB||Adobe PDF||Ver/Abrir Acesso Restrito. Solicitar cópia ao autor!|
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.