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Publication
Chromatographic-Based Platforms as New Avenues for Scientific Progress and Sustainability
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Advisor(s)
Abstract(s)
Chromatography was born approximately one century ago and has undergone outstanding
technological improvements in innovation, research, and development since then that has made it
fundamental to advances in knowledge at different levels, with a relevant impact on the well-being
and health of individuals. Chromatography boosted a comprehensive and deeper understanding of
the complexity and diversity of human–environment interactions and systems, how these interactions
affect our life, and the several societal challenges we are currently facing, namely those related to the
sustainability of our planet and the future generations. From the life sciences, which allowed us to
identify endogenous metabolites relevant to disease mechanisms, to the OMICS field, nanotechnology,
clinical and forensic analysis, drug discovery, environment, and “foodprint”, among others, the wide
range of applications of today’s chromatographic techniques is impressive. This is fueled by a great
variability of powerful chromatographic instruments currently available, with very high sensitivity,
resolution, and identification capacity, that provide a strong basis for an analytical platform able to
support the challenging demands of the postgenomic and post COVID-19 eras. Within this context,
this review aims to address the great utility of chromatography in helping to cope with several
societal-based challenges, such as the characterization of disease and/or physiological status, and the
response to current agri-food industry challenges of food safety and sustainability, or the monitoring
of environmental contamination. These are increasingly important challenges considering the climate
changes, the tons of food waste produced every day, and the exponential growth of the human
population. In this context, the principles governing the separation mechanisms in chromatography
as well the different types and chromatographic techniques will be described. In addition, the major
achievements and the most important technological advances will be also highlighted. Finally, a set
of studies was selected in order to evince the importance of different chromatographic analyses to
understand processes or create fundamental information in the response to current societal challenges.
Description
Keywords
Gas chromatography Liquid chromatography Multidimensionality Detectors Major achievements Science advances Societal challenge . Centro de Química da Madeira Faculdade de Ciências Exatas e da Engenharia
Citation
Câmara, J.S.; Martins, C.; Pereira, J.A.M.; Perestrelo, R.; Rocha, S.M. Chromatographic-Based Platforms as New Avenues for Scientific Progress and Sustainability. Molecules 2022, 27, 5267. https:// doi.org/10.3390/molecules27165267
Publisher
MDPI