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Neuroimaging studies on familiarity of music in children with autism spectrum disorder

datacite.subject.fosCiências Médicaspt_PT
dc.contributor.authorFreitas, Carina Patrícia de Barros
dc.date.accessioned2022-06-08T10:11:30Z
dc.date.available2022-06-08T10:11:30Z
dc.date.issued2020
dc.description.abstractThe field of music neuroscience allows us to use music to investigate human cognition in vivo. Examining how brain processes familiar and unfamiliar music can elucidate underlying neural mechanisms of several cognitive processes. To date, familiarity in music listening and its neural correlates in typical adults have been investigated using a variety of neuroimaging techniques, yet the results are inconsistent. In addition, these correlates and respective functional connectivity related to music familiarity in typically developing (TD) children and children with autism spectrum disorder (ASD) are unknown. The present work consists of two studies. The first one reviews and qualitatively synthesizes relevant literature on the neural correlates of music familiarity, in healthy adult populations, using different neuroimaging methods. Then it estimates the brain areas most active when listening to familiar and unfamiliar musical excerpts using a coordinate-based meta-analyses technique of neuroimaging data. We established that motor brain structures were consistently active during familiar music listening. The activation of these motor-related areas could reflect audio-motor synchronization to elements of the music, such as rhythm and melody, so that one can tap, dance and “covert” sing along with a known song. Results from this research guided our second study. This work investigated the familiarity effect in music listening in both TD and ASD children, using magnetoencephalography (MEG). This technique enabled us to study brain connectivity and characterize the networks and frequency bands involved while listening to familiar and unfamiliar songs. TD children recruited a similar brain network as those in typical adults during familiar music listening, in the gamma frequency band. Compared to TD, children with ASD showed relatively intact processing of familiar songs but atypical processing of unfamiliar songs in theta and beta-bands. Atypical functional connectivity of other unfamiliar stimuli has been reported in ASD. Our findings reinforced that processing novelty is a challenge. Overall, this work contributes to the advancement of both fields of music neuroscience and brain connectivity in ASD.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4317
dc.language.isoengpt_PT
dc.relationNeuroimaging studies on familiarity and likeability of music in children with autism spectrum disorder
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAutism spectrum disorderpt_PT
dc.subjectAutismpt_PT
dc.subjectChildrenpt_PT
dc.subjectMusicpt_PT
dc.subjectNeuroimagingpt_PT
dc.subjectPhilosophypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleNeuroimaging studies on familiarity of music in children with autism spectrum disorderpt_PT
dc.typedoctoral thesis
dspace.entity.typePublication
oaire.awardTitleNeuroimaging studies on familiarity and likeability of music in children with autism spectrum disorder
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F116213%2F2016/PT
person.familyNameDe Barros Freitas
person.givenNameCarina Patrícia
person.identifier.ciencia-id1616-9C71-0359
person.identifier.orcid0000-0002-3713-9386
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typedoctoralThesispt_PT
relation.isAuthorOfPublication2caaa44a-cb70-4016-ade0-2426574e24df
relation.isAuthorOfPublication.latestForDiscovery2caaa44a-cb70-4016-ade0-2426574e24df
relation.isProjectOfPublication257ed3e4-0d37-4773-ab0b-e0c4a9014113
relation.isProjectOfPublication.latestForDiscovery257ed3e4-0d37-4773-ab0b-e0c4a9014113
thesis.degree.nameDegree of Philosophy Institute of Medical Science University of Torontopt_PT

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