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Browsing by Author "Abreu, S."

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  • Human leucocyte antigens class II allele and haplotype association with Type 1 Diabetes in Madeira Island (Portugal)
    Publication . Spínola, H.; Lemos, A.; Couto, A. R.; Parreira, A.; Soares, M.; Dutra, I.; Bruges-Armas, J.; Brehm, A.; Abreu, S.
    This study confirms for Madeira Island (Portugal) population the Type 1 Diabetes (T1D) susceptible and protective Human leucocyte antigens (HLA) markers previously reported in other populations and adds some local specificities. Among the strongest T1D HLA associations, stands out, as susceptible, the alleles DRB1*04:05 (OR = 7.3), DQB1*03:02 (OR = 6.1) and DQA1*03:03 (OR = 4.5), as well as the haplotypes DRB1*04:05- DQA1*03:03- DQB1*03:02 (OR = 100.9) and DRB1*04:04- DQA1*03:01- DQB1*03:02 (OR = 22.1), and DQB1*06:02 (OR = 0.07) and DRB1*15:01- DQA1*01:02- DQB1*06:02 (OR = 0.04) as protective. HLA- DQA1 positive for Arginine at position 52 (Arg52) (OR = 15.2) and HLA- DQB1 negative for Aspartic acid at the position 57 (Asp57) (OR = 9.0) alleles appear to be important genetic markers for T1D susceptibility, with higher odds ratio values than any single allele and than most of the haplotypes. Genotypes generated by the association of markers Arg52 DQA1 positive and Asp57 DQB1 negative increase T1D susceptibility much more than one would expected by a simple additive effect of those markers separately (OR = 26.9). This study also confirms an increased risk for DRB1*04/DRB1*03 heterozygote genotypes (OR = 16.8) and also a DRB1*04- DQA1*03:01- DQB1*03:02 haplotype susceptibility dependent on the DRB1*04 allele (DRB1*04:01, OR = 7.9; DRB1*04:02, OR = 3.2; DRB1*04:04, OR = 22.1).
    2017Journal article Restricted access Show more
  • Learning to be critical with mathematics: body mass index
    Publication . Abreu, S.; Fernandes, E.
    This paper presents part of an investigation from the first author’s master, whose aim was to discuss how Critical Mathematics Education in school contributes to the formation of critical and responsible citizens. The empirical basis of this study consisted in the implementation of a learning scenario which purpose was to work with students the critical analysis of some news in newspapers and magazines, whose topics were focused on Body Mass Index. Given the stated purpose of the study, we choose a qualitative research methodology with interpretative nature.
    2015Conference object Open access Show more