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- In-situ biosynthesis of bacterial cellulose - Porto Santo clay composites: application in drug deliveryPublication . Pinto, Rafael Olegário Sousa; Cordeiro, Nereida Maria AbanoBacterial cellulose/clay composites have been lately receiving attention by the scientific community towards drug delivery systems and wound dressing applications. The current work aims to determine the most suitable culture conditions to obtain an effective drug delivery membrane through an environmentally-friendly method. Thus, the BCC composites were synthesized by BC-producing bacteria, Gluconacetobacter sp., using an in-situ biosynthesis method. Gluconacetobacter sp. produced 2.95 g/L BC at optimized culture conditions of 2% glucose, pH of 3.25 and 7 days of cultivation. To obtain the different BCC composites, an agitated culture method was employed. The results show that the introduction of PS clay onto BC obstructed the pores of the synthetized composites, which led into a less porous and more compact material. Additionally, an increase in ϒsd (79%), surface basicity (Kb/Ka → 4.2) and thermal stability (83%) of BC was observed. The composites with incorporated 2% neomycin sulphate were evaluated in terms of their drug release ability and antibacterial activities. These materials exhibited a sustained release up to 24h in a PBS buffer with pH 7.4, whereby they could be used as capsules for oral administration, in the treatment of ileum infections. Furthermore, BCC composites with incorporated neomycin sulphate could be applied as clinical wound healing materials due to their strong antibacterial activities against Staphylococcus aureus and Escherichia coli.