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HLA genes in Madeira Island (Portugal) inferred from sequence-based typing: footprints from different origins

2006Journal article Restricted access
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dc.contributor.authorSpínola, Hélder
dc.contributor.authorBruges-Armas, Jácome
dc.contributor.authorMora, Marian Gantes
dc.contributor.authorMiddleton, Derek
dc.contributor.authorBrehm, António
dc.date.accessioned2018-11-13T11:51:52Z
dc.date.available2018-11-13T11:51:52Z
dc.date.issued2006
dc.description.abstractHuman leukocyte antigen (HLA)-A, HLA-B, and HLA-DRB1 polymorphisms were examined in Madeira Island populations. The data was obtained at high-resolution level, using sequence-based typing (SBT). The most frequent alleles at each loci were: A*020101 (24.6%), B*5101 (9.7%), B*440201 (9.2%), and DRB1*070101 (15.7%). The predominant three-loci haplotypes in Madeira were A*020101–B*510101–DRB1*130101 (2.7%) and A*010101–B*0801–DRB1*030101 (2.4%), previously found in north and central Portugal. The present study corroborates historical sources and other genetic studies that say Madeira were populated not only by Europeans, mostly Portuguese, but also sub-Saharan Africans due to slave trade. Comparison with other populations shows that Madeira experienced a stronger African influence due to slave trade than Portugal mainland and even the Azores archipelago. Despite this African genetic input, haplotype and allele frequencies were predominantly from European origin, mostly common to mainland Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, H., Bruges-Armas, J., Mora, M. G., Middleton, D., & Brehm, A. (2006). HLA genes in Madeira Island (Portugal) inferred from sequence-based typing: footprints from different origins. Molecular Immunology, 43(10), 1726-1728.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2162
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.subjectHLA polymorphismpt_PT
dc.subjectSequence-based typingpt_PT
dc.subjectMadeira Island (Portugal)pt_PT
dc.subject.pt_PT
dc.subjectEscola Superior de Tecnologias e Gestãopt_PT
dc.titleHLA genes in Madeira Island (Portugal) inferred from sequence-based typing: footprints from different originspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1728
oaire.citation.startPage1726
oaire.citation.titleMolecular Immunologypt_PT
oaire.citation.volume43(10)pt_PT
person.familyNameSpínola
person.familyNameArmas
person.familyNameBrehm
person.givenNameHélder
person.givenNameJacome
person.givenNameAntonio
person.identifier682991
person.identifier.ciencia-id8413-FBC3-5584
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0002-6455-1595
person.identifier.orcid0000-0001-7671-6521
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-id10242534600
person.identifier.scopus-author-id55931428200
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ba0f1f6-73c8-46b2-b152-8cd3c90207ed
relation.isAuthorOfPublication887d1c55-c104-403c-b73e-acfa317c4e5d
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery62d279e2-247a-4652-a370-3e8c2a846e31

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