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Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

2016Journal article Open access
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dc.contributor.authorSilventoinen, Karri
dc.contributor.authorJelenkovic, Aline
dc.contributor.authorSund, Reijo
dc.contributor.authorHur, Yoon-Mi
dc.contributor.authorYokoyama, Yoshie
dc.contributor.authorHonda, Chika
dc.contributor.authorHjelmborg, Jacob vB
dc.contributor.authorMöller, Sören
dc.contributor.authorOoki, Syuichi
dc.contributor.authorAaltonen, Sari
dc.contributor.authorJi, Fuling
dc.contributor.authorSaudino, Kimberly J
dc.contributor.authorJang, Kerry L
dc.contributor.authorCozen, Wendy
dc.contributor.authorHwang, Amie E
dc.contributor.authorMack, Thomas M.
dc.contributor.authorGao, Wenjing
dc.contributor.authorYu, Canqing
dc.contributor.authorLi, Liming
dc.contributor.authorCorley, Robin P.
dc.contributor.authorHuibregtse, Brooke M
dc.contributor.authorChristensen, Kaare
dc.contributor.authorSkytthe, Axel
dc.contributor.authorKyvik, Kirsten O
dc.contributor.authorDerom, Catherine A.
dc.contributor.authorVlietinck, Robert F.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorHeikkilä, Kauko
dc.contributor.authorWardle, Jane
dc.contributor.authorLlewellyn, Clare H.
dc.contributor.authorFisher, Abigail
dc.contributor.authorMcAdams, Tom A
dc.contributor.authorEley, Thalia C.
dc.contributor.authorGregory, Alice M
dc.contributor.authorHe, Mingguang
dc.contributor.authorDing, Xiaohu
dc.contributor.authorBjerregaard-Andersen, Morten
dc.contributor.authorBeck-Nielsen, Henning
dc.contributor.authorSodemann, Morten
dc.contributor.authorTarnoki, Adam D.
dc.contributor.authorTarnoki, David L.
dc.contributor.authorStazi, Maria A
dc.contributor.authorFagnani, Corrado
dc.contributor.authorD’Ippolito, Cristina
dc.contributor.authorKnafo-Noam, Ariel
dc.contributor.authorMankuta, David
dc.contributor.authorAbramson, Lior
dc.contributor.authorBurt, S. Alexandra
dc.contributor.authorKlump, Kelly L.
dc.contributor.authorSilberg, Judy L
dc.contributor.authorEaves, Lindon J.
dc.contributor.authorMaes, Hermine H.
dc.contributor.authorKrueger, Robert F
dc.contributor.authorMcGue, Matt
dc.contributor.authorPahlen, Shandell
dc.contributor.authorGatz, Margaret
dc.contributor.authorButler, David A.
dc.contributor.authorBartels, Meike
dc.contributor.authorvan Beijsterveldt, Toos CEM
dc.contributor.authorCraig, Jeffrey M.
dc.contributor.authorSaffery, Richard
dc.contributor.authorFreitas, Duarte L.
dc.contributor.authorMaia, José Antonio
dc.contributor.authorDubois, Lise
dc.contributor.authorBoivin, Michel
dc.contributor.authorBrendgen, Mara
dc.contributor.authorDionne, Ginette
dc.contributor.authorVitaro, Frank
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMedland, Sarah E
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorChong, Youngsook
dc.contributor.authorSwan, Gary E.
dc.contributor.authorKrasnow, Ruth
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorTynelius, Per
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorHaworth, Claire MA
dc.contributor.authorPlomin, Robert
dc.contributor.authorBayasgalan, Gombojav
dc.contributor.authorNarandalai, Danshiitsoodol
dc.contributor.authorHarden, K Paige
dc.contributor.authorTucker-Drob, Elliot M.
dc.contributor.authorÖncel, Sevgi Y
dc.contributor.authorAliev, Fazil
dc.contributor.authorSpector, Timothy
dc.contributor.authorMangino, Massimo
dc.contributor.authorLachance, Genevieve
dc.contributor.authorBaker, Laura A.
dc.contributor.authorTuvblad, Catherine
dc.contributor.authorDuncan, Glen E.
dc.contributor.authorBuchwald, Dedra
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorRasmussen, Finn
dc.contributor.authorGoldberg, Jack H
dc.contributor.authorSørensen, Thorkild IA
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorNing, Feng
dc.contributor.authorPang, Zengchang
dc.contributor.authorRebato, Esther
dc.contributor.authorBusjahn, Andreas
dc.contributor.authorKandler, Christian
dc.date.accessioned2021-09-17T09:15:54Z
dc.date.available2021-09-17T09:15:54Z
dc.date.issued2016
dc.description.abstractBackground: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contribu tions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and en vironmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a ma jor role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilventoinen, K., Jelenkovic, A., Sund, R., Hur, Y. M., Yokoyama, Y., Honda, C., ... & Kaprio, J. (2016). Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. The American journal of clinical nutrition, 104(2), 371-379. https://doi.org/10.3945/ajcn.116.130252pt_PT
dc.identifier.doi10.3945/ajcn.116.130252pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3639
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Nutritionpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBMIpt_PT
dc.subjectChildrenpt_PT
dc.subjectGeneticspt_PT
dc.subjectInternational comparisonspt_PT
dc.subjectTwinpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Sociaispt_PT
dc.titleGenetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage379pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage371pt_PT
oaire.citation.titleThe American Journal of Clinical Nutritionpt_PT
oaire.citation.volume104pt_PT
person.familyNameFreitas
person.familyNameKaprio
person.givenNameDuarte
person.givenNameJaakko
person.identifier.ciencia-idAA13-1821-A447
person.identifier.orcid0000-0001-6642-3370
person.identifier.orcid0000-0002-3716-2455
person.identifier.scopus-author-id37096975400
person.identifier.scopus-author-id35379599600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdfbe8c6f-691e-439f-b06e-832f0d8c1fa5
relation.isAuthorOfPublicationcda7cc68-24f8-49be-a0af-01f01b4f3475
relation.isAuthorOfPublication.latestForDiscoverydfbe8c6f-691e-439f-b06e-832f0d8c1fa5

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