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Inhibition of α-amylase, α-glucosidase and pancreatic lipase by phenolic compounds of Rumex maderensis (Madeira sorrel). Influence of simulated gastrointestinal digestion on hyperglycaemia-related damage linked with aldose reductase activity and protein glycation

2020Journal article Open access
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dc.contributor.authorSpínola, Vítor
dc.contributor.authorLlorent-Martínez, Eulogio J.
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-24T15:25:07Z
dc.date.available2021-03-24T15:25:07Z
dc.date.issued2020
dc.description.abstractIn this work, we report the in vitro inhibitory potential of Rumex maderensis methanolic extracts (leaves, flowers, and stems) towards key digestive enzymes linked to type-2 diabetes and obesity (α-amylase, α-glucosidase, pancreatic lipase). The inhibitory activity towards aldose reductase and glycation of bovine serum albumin (BSA) is also reported; in these latter assays, the effect of simulated digestion on the bioactivities was evaluated. The inhibitory activities of R. maderensis extracts were statistically compared with the inhibition produced by reference compounds for each assay. The analysed extracts exhibited significant inhibitory activities, which decreased after the gastrointestinal digestion, possibly due to some loss of phenolics that took place during the digestion process. The most important results were observed during the BSA-glycation assay, in which the analysed extracts presented higher potency than a reference compound: aminoguanidine (AMG). This research is the first showing the potential anti-diabetic activity of R. maderensis.pt_PT
dc.description.sponsorshipThe authors are grateful to Francisco Fernandes and José Carvalho from Madeira Botanical Garden (Funchal) for the identification of plant material. V. Spínola acknowledges Fundação para a Ciência e a Tecnologia (FCT, Portugal) for a Ph.D. grant SFRH/BD/84672/2012. This work was also supported by FCT (project PEst-OE/QUI/UI0674/ 2019, CQM, Portuguese Government funds) and the Portuguese National Mass Spectrometry Network (Contract RNEMREDE/1508/ REM/2005), and through Madeira 14–20 Program, project PROEQUIPRAM - Reforço do Investimento em Equipamentos e Infraestruturas Científicas na RAM (M1420-01-0145-FEDER-000008) and by ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação, through the project M1420-01- 0145-FEDER-000005 - Centro de Química da Madeira - CQM+ (Madeira 14–20).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, V., Llorent-Martínez, E. J., & Castilho, P. C. (2020). Inhibition of α-amylase, α-glucosidase and pancreatic lipase by phenolic compounds of Rumex maderensis (Madeira sorrel). Influence of simulated gastrointestinal digestion on hyperglycaemia-related damage linked with aldose reductase activity and protein glycation. LWT, 118, 108727. https://doi.org/10.1016/j.lwt.2019.108727pt_PT
dc.identifier.doi10.1016/j.lwt.2019.108727pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3197
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectRumex maderensispt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectDigestive enzymes inhibitionpt_PT
dc.subjectAldose reductasept_PT
dc.subjectBSA glycationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleInhibition of α-amylase, α-glucosidase and pancreatic lipase by phenolic compounds of Rumex maderensis (Madeira sorrel). Influence of simulated gastrointestinal digestion on hyperglycaemia-related damage linked with aldose reductase activity and protein glycationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F84672%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.startPage108727pt_PT
oaire.citation.titleLWTpt_PT
oaire.citation.volume118pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSpínola
person.familyNameCastilho
person.givenNameVítor
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0003-2456-8613
person.identifier.orcid0000-0002-8303-4286
person.identifier.scopus-author-id54881258000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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