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Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery

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dc.contributor.authorZhan, Yuan
dc.contributor.authorGonƧalves, Mara
dc.contributor.authorYi, Panpan
dc.contributor.authorCapelo, DĆ©bora
dc.contributor.authorZhang, Yuhong
dc.contributor.authorRodrigues, JoĆ£o
dc.contributor.authorLiu, Changsheng
dc.contributor.authorTomƔs, Helena
dc.contributor.authorLi, Yulin
dc.contributor.authorHe, Peixin
dc.date.accessioned2019-06-24T10:37:57Z
dc.date.available2019-06-24T10:37:57Z
dc.date.issued2015
dc.description.abstractThe clinical application of doxorubicin (DOX), like other anticancer drugs, is limited by insuļ¬ƒcient cellular uptake and the numerous drug resistance mechanisms existing in cells. The development of smart nanomaterials capable of carrying the drugs into the cells and of releasing them under the control of the microenvironment is an interesting approach that may increase the success of the anticancer drugs currently in use. Herein, we report an easy process to prepare biocompatible nanogels (NGs) with thermo/ redox/pH-triple sensitivity, which are highly eļ¬€ective in the intracellular delivery of DOX. Redox-sensitive/ degradable NGs (PNA-BAC) and nondegradable NGs (PNA-MBA) were prepared through in situ polymerization of N-isopropylacrylamide (NIPAM) and acrylic acid (AA) in the presence of sodium dodecyl sulfate (SDS) as a surfactant, using N,N0-bis(acryloyl)cystamine (BAC) as a biodegradable crosslinker or N,N0-methylene bisacrylamide (MBA) as a nondegradable crosslinker, respectively. After that, the cationic DOX drug was loaded into the NGs through electrostatic interactions, by simply mixing them in aqueous solution. Compared to nondegradable PNA-MBA NGs, PNA-BAC NGs not only presented a higher DOX drug loading capacity, but also allowed a more sustainable drug release behavior under physiological conditions. More importantly, PNA-BAC NGs displayed thermo-induced drug release properties and an in vitro accelerated release of DOX under conditions that mimic intracellular reductive conditions and acidic tumor microenvironments. The thermo/redox/pH multi-sensitive NGs can quickly be taken up by CAL-72 cells (an osteosarcoma cell line), resulting in a high DOX intracellular accumulation and an improved cytotoxicity when compared with free DOX and DOX-loaded nondegradable PNA-MBA NGs. The developed NGs can be possibly used as an eļ¬€ective platform for the delivery of cationic therapeutic agents for biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZhan, Y., GonƧalves, M., Yi, P., Capelo, D., Zhang, Y., Rodrigues, J., ... & He, P. (2015). Thermo/redox/pH-triple sensitive poly (N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery. Journal of Materials Chemistry B, 3(20), 4221-4230.pt_PT
dc.identifier.doi10.1039/C5TB00468Cpt_PT
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/10400.13/2421
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
dc.subjectThermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogelspt_PT
dc.subjectAnticancer drug deliverypt_PT
dc.subject.
dc.subjectFaculdade de CiĆŖncias Exatas e da Engenharia
dc.subjectCentro de QuĆ­mica da Madeira
dc.titleThermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F116788%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88721%2F2012/PT
oaire.citation.endPage4230pt_PT
oaire.citation.startPage4221pt_PT
oaire.citation.titleJournal of Materials Chemistry Bpt_PT
oaire.citation.volume3(20)pt_PT
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameGonƧalves
person.familyNameRodrigues
person.familyNameTomƔs
person.familyNameLi
person.givenNameMara
person.givenNameJoĆ£o
person.givenNameHelena
person.givenNameYulin
person.identifier556975
person.identifier.ciencia-id6010-1863-4B11
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0002-0332-3548
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-5569-1038
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.ridA-4082-2013
person.identifier.scopus-author-id55509603000
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id55718977200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery53031fca-b2e7-4ce4-bda9-61e486da4547
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