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Microalgae and cyanobacteria as natural sources of antioxidant enzymes and enzyme inhibitors for Alzheimer's and diabetes

2024-08Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
dc.contributor.authorOdenthal, Kilian
dc.contributor.authorNunes, Emmanuel
dc.contributor.authorNunes, Nuno
dc.contributor.authorFernandes, Tomásia
dc.contributor.authorFernandes, Igor A.
dc.contributor.authorCarvalho, Miguel A. A. Pinheiro de
dc.contributor.authorNunes, Nuno
dc.contributor.authorFernandes, Tomásia
dc.contributor.authorAlmeida Pinheiro de Carvalho, Miguel Angelo
dc.date.accessioned2025-05-05T10:51:24Z
dc.date.available2025-05-05T10:51:24Z
dc.date.issued2024-08
dc.description.abstractMicroalgae and cyanobacteria biomass can be cultivated in large amounts, producing a variety of bioactive compounds. As a result, various industries have begun to study the potential of this biomass in a wide range of applications such as biofuel production, environmental remediation for contaminated soil and water, food supplements, and as a source of feed for aquaculture. The cultivation conditions have a profound impact on microalgae biochemical composition. Therefore, the culture conditions must be tailored to the specific appli cation of the biomass. This entails careful control of factors such as light exposure, nutrient concentration, and the application of stress conditions. To further enhance the value of microalgae biomass beyond its nutritional analysis, this review aims to explore the potential of the biomass as biofactories for producing antioxidant en zymes and inhibitors targeting Alzheimer's and diabetes diseases. Both chronic diseases are a growing concern due to an aging population and an increase in obesity rates. Microalgae when exposed to stressful conditions enhance the activity of antioxidant enzymes. However, further studies in the isolation and storage of these en zymes need to be performed. From the literature reviewed microalgae exhibited great potential in inhibiting key enzymes involved in Alzheimer's and Diabetes. The inhibitory potential was observed both in vitro and at a cellular level making them a promising natural alternative to current medication used to inhibit these enzymes.eng
dc.identifier.citationOdenthal, K., Nunes, E., Nunes, N., Fernandes, T., Fernandes, I. A., & de Carvalho, M. A. P. (2024). Microalgae and cyanobacteria as natural sources of antioxidant enzymes and enzyme inhibitors for Alzheimer's and diabetes. Algal Research, 82, 103610.
dc.identifier.doi10.1016/j.algal.2024.103610
dc.identifier.issn2211-9264
dc.identifier.urihttp://hdl.handle.net/10400.13/7254
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relation.ispartofAlgal Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMicroalgae
dc.subjectCyanobacteria
dc.subjectAntioxidant enzymes
dc.subjectAlzheimer's
dc.subjectDiabetes
dc.subject.
dc.subjectFaculdade de Ciências da Vida
dc.titleMicroalgae and cyanobacteria as natural sources of antioxidant enzymes and enzyme inhibitors for Alzheimer's and diabeteseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.citation.titleAlgal Research
oaire.citation.volume82
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNunes
person.familyNameFernandes
person.familyNameAlmeida Pinheiro de Carvalho
person.givenNameNuno
person.givenNameTomásia
person.givenNameMiguel Angelo
person.identifier1379802
person.identifier1218558
person.identifier.ciencia-idDE1D-5AAF-B0A9
person.identifier.ciencia-id4610-6741-6816
person.identifier.orcid0000-0002-2498-0643
person.identifier.orcid0000-0002-6157-4177
person.identifier.orcid0000-0002-5084-870X
person.identifier.ridM-4006-2013
person.identifier.ridAEE-0913-2022
person.identifier.scopus-author-id8704415000
person.identifier.scopus-author-id8758577600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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