A carregar...
Publicação
Caffeoylquinic acids as inhibitors for HIV-I protease and HIV-I integrase: a molecular docking study
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 370.76 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Caffeoylquinic acids are ubiquitous phenolic compounds with several health benefits to humans and they
have been shown to be promisinganti-HIV compounds. In this work, molecular docking was used to study
the inhibition of HIV-I integrase and protease using caffeoylquinic acids. It was possible to establish that the
naturally occurring caffeoylquinic acids are not suitable as inhibitors for protease but are very good
inhibitors for integrase. A new binding site was found for 3, 4-O-di-Caffeoylquinic acid between the chains of
HIV-I integrase that could possibly lead to a disruption of the catalytic process of HIV-I integrase.
Descrição
Palavras-chave
HIV Integrase Protease Molecular docking In silico Caffeoylquinic acid Enzyme inhibition . Faculdade de Ciências Exatas e da Engenharia
Contexto Educativo
Citação
Serina, J. C., Castilho, P. C., Fernandes, M. X., & Desk, S. (2016). Caffeoylquinic acids as inhibitors for HIV-I protease and HIV-I Integrase. A Molecular docking study. SDRP Journal of Computational Chemistry & Molecular Modelling, 1(2).