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Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection

2015Journal article Open access
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dc.contributor.authorPopov, Serguey S.
dc.contributor.authorShulgin, Konstantin K.
dc.contributor.authorPopova, Tatyana N.
dc.contributor.authorPashkov, Aleksander N.
dc.contributor.authorAgarkov, Aleksander A.
dc.contributor.authorCarvalho, Miguel A. A. Pinheiro de
dc.date.accessioned2021-03-15T09:51:40Z
dc.date.available2021-03-15T09:51:40Z
dc.date.issued2015
dc.description.abstractAcute hepatitis results from oxidative stress triggered by hepatotoxic drugs causing liver injury and the activation of caspases cascade. The glutathione antioxidant system protects against reactive oxygen species and mitigates development of these processes. The effectiveness of silymarin, a polyphenolic flavonoid, essenthiale, composed of phosphatidyl choline, and melaxen, a melatonin-correcting drug, as hepatoprotectors has been investigated. The variation of 6-sulfatoxymelatonin (aMT6s), resulting from the biotransformation of melatonin, and GSH has been measured. The activities of caspase-1 and caspase-3, glutathione antioxidant system, and NADPH-generating enzymes were determined. The aMT6s decreases in patients with drug hepatitis and recovers with administration of mexalen. GSH increased in the presence of the studied hepatoprotectors. Pathologically activated caspase-1 and caspase-3 decreased their activities in the presence of hepatoprotectors with melaxen showing the highest effect. The positive effect of melatonin appears to be related to the suppression of decompensation of the glutathione antioxidant system functions, recovery of liver redox status, and the attenuation of inhibition of the NADPH supply.pt_PT
dc.description.sponsorshipThis work was supported by grant of the President of the Russian Federation for young scientists MK- 3133.2011.7. Authors thank to President of Voronezh State Medical Academy named after N. N. Burdenko (Russia), Prof. Igor E. Esaulenko, for advice and suggestions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPopov, S. S., Shulgin, K. K., Popova, T. N., Pashkov, A. N., Agarkov, A. A., & Carvalho, M. A. P. (2015). Effects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protection. Journal of biochemical and molecular toxicology, 29(10), 449-457. https://doi.org/10.1002/jbt.21705pt_PT
dc.identifier.doi10.1002/jbt.21705pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3168
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDrug-induced hepatitispt_PT
dc.subjectGlutathione antioxidant systempt_PT
dc.subject6-Sulfatoxymelatoninpt_PT
dc.subjectReduced gluthationept_PT
dc.subjectHepatoprotectorspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleEffects of Melatonin-aided therapy on the Glutathione antioxidant system activity and liver protectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage457pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage449pt_PT
oaire.citation.titleJournal of Biochemical and Molecular Toxicologypt_PT
oaire.citation.volume29pt_PT
person.familyNameAlmeida Pinheiro de Carvalho
person.givenNameMiguel Angelo
person.identifier1218558
person.identifier.ciencia-id4610-6741-6816
person.identifier.orcid0000-0002-5084-870X
person.identifier.ridAEE-0913-2022
person.identifier.scopus-author-id8758577600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2e433c48-88f8-40a2-b21f-de78b44aab1c
relation.isAuthorOfPublication.latestForDiscovery2e433c48-88f8-40a2-b21f-de78b44aab1c

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