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HLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typing

2005-10Journal article Restricted access
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dc.contributor.authorSpínola, Hélder
dc.contributor.authorBruges-Armas, Jácome
dc.contributor.authorMiddleton, Derek
dc.contributor.authorBrehm, António
dc.date.accessioned2018-11-13T12:24:21Z
dc.date.available2018-11-13T12:24:21Z
dc.date.issued2005-10
dc.description.abstractHuman leukocyte antigen (HLA)-A, -B, and -DRB1 polymorphisms were examined in the Cabo Verde and Guiné-Bissau populations. The data were obtained at high-resolution level, using sequence-based typing. The most frequent alleles in each locus was: A*020101 (16.7% in Guiné-Bissau and 13.5% in Cabo Verde), B*350101 (14.4% in Guiné-Bissau and 13.2% in Cabo Verde), DRB1*1304 (19.6% in Guiné-Bissau), and DRB1*1101 (10.1% in Cabo Verde). The predominant three loci haplotype in Guiné-Bissau was A*2301-B*1503-DRB1*1101 (4.6%) and in Cabo Verde was A*3002-B*350101-DRB1*1001 (2.8%), exclusive to northwestern islands (5.6%) and absent in Guiné-Bissau. The present study corroborates historic sources and other genetic studies that say Cabo Verde were populated not only by Africans but also by Europeans. Haplotypes and dendrogram analysis shows a Caucasian genetic influence in today’s gene pool of Cabo Verdeans. Haplotypes and allele frequencies present a differential distribution between southeastern and northwestern Cabo Verde islands, which could be the result of different genetic influences, founder effect, or bottlenecks. Dendrograms and principal coordinates analysis show that Guineans are more similar to North Africans than other HLA-studied sub-Saharans, probably from ancient and recent genetic contacts with other peoples, namely East Africans.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, H., Bruges-Armas, J., Middleton, D., & Brehm, A. (2005). HLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typing. Human Immunology, 66(10), 1082-1092.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2163
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectHLA polymorphismpt_PT
dc.subjectSBTpt_PT
dc.subjectCabo Verdept_PT
dc.subjectGuiné-Bissaupt_PT
dc.subject.pt_PT
dc.subjectEscola Superior de Tecnologias e Gestãopt_PT
dc.titleHLA polymorphisms in Cabo Verde and Guiné-Bissau inferred from sequence-based typingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1092pt_PT
oaire.citation.startPage1082pt_PT
oaire.citation.titleHuman Immunologypt_PT
oaire.citation.volume66(10)pt_PT
person.familyNameSpínola
person.familyNameArmas
person.familyNameBrehm
person.givenNameHélder
person.givenNameJacome
person.givenNameAntonio
person.identifier682991
person.identifier.ciencia-id8413-FBC3-5584
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0002-6455-1595
person.identifier.orcid0000-0001-7671-6521
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-id10242534600
person.identifier.scopus-author-id55931428200
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ba0f1f6-73c8-46b2-b152-8cd3c90207ed
relation.isAuthorOfPublication887d1c55-c104-403c-b73e-acfa317c4e5d
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery887d1c55-c104-403c-b73e-acfa317c4e5d

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