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Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective

2007Journal article Open access
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dc.contributor.authorRosa, Alexandra
dc.contributor.authorOrnelas, Carolina
dc.contributor.authorJobling, Mark A.
dc.contributor.authorBrehm, António
dc.contributor.authorVillems, Richard
dc.date.accessioned2020-11-30T15:13:26Z
dc.date.available2020-11-30T15:13:26Z
dc.date.issued2007
dc.description.abstractThe geographic and ethnolinguistic differentiation of many African Y-chromosomal lineages provides an opportunity to evaluate human migration episodes and admixture processes, in a pan-continental context. The analysis of the paternal genetic structure of Equatorial West Africans carried out to date leaves their origins and relationships unclear, and raises questions about the existence of major demographic phenomena analogous to the large-scale Bantu expansions. To address this, we have analysed the variation of 31 binary and 11 microsatellite markers on the non-recombining portion of the Y chromosome in Guinea-Bissau samples of diverse ethnic affiliations, some not studied before.Results: The Guinea-Bissau Y chromosome pool is characterized by low haplogroup diversity (D = 0.470, sd 0.033), with the predominant haplogroup E3a*-M2 shared among the ethnic clusters and reaching a maximum of 82.2% in the Mandenka people. The Felupe-Djola and Papel groups exhibit the highest diversity of lineages and harbor the deep-rooting haplogroups A-M91, E2-M75 and E3*-PN2, typical of Sahel's more central and eastern areas. Their genetic distinction from other groups is statistically significant (P = 0.01) though not attributable to linguistic, geographic or religious criteria. Non sub-Saharan influences were associated with the presence of haplogroup R1b-P25 and particular lineages of E3b1-M78. Conclusion: The predominance and high diversity of haplogroup E3a*-M2 suggests a demographic expansion in the equatorial western fringe, possibly supported by a local agricultural center. The paternal pool of the Mandenka and Balanta displays evidence of a particularly marked population growth among the Guineans, possibly reflecting the demographic effects of the agriculturalist lifestyle and their putative relationship to the people that introduced early cultivation practices into West Africa. The paternal background of the Felupe-Djola and Papel ethnic groups suggests a better conserved ancestral pool deriving from East Africa, from where they have supposedly migrated in recent times. Despite the overall homogeneity in a multiethnic sample, which contrasts with their social structure, minor clusters suggest the imprints of multiple peoples at different timescales: traces of ancestral inhabitants in haplogroups AM91 and B-M60, today typical of hunter-gatherers; North African influence in E3b1-M78 Y chromosomes, probably due to trans-Saharan contacts; and R1b-P25 lineages reflecting European admixture via the North Atlantic slave trade.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRosa, A., Ornelas, C., Jobling, M. A., Brehm, A., & Villems, R. (2007). Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective. BMC Evolutionary Biology, 7(1), 1-11.pt_PT
dc.identifier.doi10.1186/1471-2148-7-124pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3014
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationCARACTERIZAÇÃO DO PERFIL GENÉTICO DOS GUINEENSES COM BASE EM MARCADORES GENÉTICOS MITOCONDRIAIS E DO CROMOSSOMA Y
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAfrican continental ancestry grouppt_PT
dc.subjectAnalysis of variancept_PT
dc.subjectChromosome mappingpt_PT
dc.subjectChromosomes, Human, Ypt_PT
dc.subjectDNA, Mitochondrialpt_PT
dc.subjectEthnic Groupspt_PT
dc.subjectGuinea-Bissaupt_PT
dc.subjectHaplotypespt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMicrosatellite Repeatspt_PT
dc.subjectPhylogenypt_PT
dc.subjectPolymorphism, Restriction Fragment Lengthpt_PT
dc.subjectPolymorphism, Single Nucleotidept_PT
dc.subjectGenetic Variationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleY-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspectivept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCARACTERIZAÇÃO DO PERFIL GENÉTICO DOS GUINEENSES COM BASE EM MARCADORES GENÉTICOS MITOCONDRIAIS E DO CROMOSSOMA Y
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F12173%2F2003/PT
oaire.citation.endPage11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBMC Evolutionary Biologypt_PT
oaire.citation.volume7(1)pt_PT
person.familyNameda Silva Rosa
person.familyNameBrehm
person.givenNamePatrícia Alexandra
person.givenNameAntonio
person.identifier.ciencia-idF01B-3B5B-2269
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0002-1827-6828
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-idAuthor ID 7006085833
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
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