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Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade

2001Journal article Open access
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dc.contributor.authorBandelt, H.-J.
dc.contributor.authorAlves-Silva, J.
dc.contributor.authorGuimarães, P. E. M.
dc.contributor.authorSantos, M. S.
dc.contributor.authorBrehm, A.
dc.contributor.authorPereira, L.
dc.contributor.authorCoppa, A.
dc.contributor.authorLarruga, J. M.
dc.contributor.authorRengo, C.
dc.contributor.authorScozzari, R.
dc.contributor.authorTorroni, A.
dc.contributor.authorPrata, M. J.
dc.contributor.authorAmorim, A.
dc.contributor.authorPrado, V. F.
dc.contributor.authorPena, S. D. J.
dc.date.accessioned2020-12-30T11:15:02Z
dc.date.available2020-12-30T11:15:02Z
dc.date.issued2001
dc.description.abstractThe mtDNA haplogroup L3e, which is identified by the restriction site ­2349 MboI within the Afro-Eurasian superhaplogroup L3 (®3592 HpaI), is omnipresent in Africa but virtually absent in Eurasia (except for neighbouring areas with limited genetic exchange). L3e was hitherto poorly characterised in terms of HVS-I motifs, as the ancestral HVS-I type of L3e cannot be distinguished from the putative HVS-I ancestor of the entire L3 (differing from the CRS by a transition at np 16223). An MboI screening at np 2349 of a large number of Brazilian and Caribbean mtDNAs (encompassing numerous mtDNAs of African ancestry), now reveals that L3e is subdivided into four principal clades, each characterised by a single mutation in HVS-I, with additional support coming from HVS-II and partial RFLP analysis. The apparently oldest of these clades (transition at np 16327) occurs mainly in central Africa and was probably carried to southern Africa with the Bantu expansion(s). The most frequent clade (transition at np 16320) testifies to a pronounced expansion event in the mid-Holocene and seems to be prominent in many Bantu groups from all of Africa. In contrast, one clade (transition at np 16264) is essentially restricted to Atlantic western Africa (including Cabo Verde). We propose a tentative L3e phylogeny that is based on 197 HVS-I sequences. We conclude that haplogroup L3e originated in central or eastern Africa about 46,000 (³14,000) years ago, and was a hitchhiker of much later dispersal and local expansion events, with the rise of food production and iron smelting. Enforced migration of African slaves to the Americas translocated L3e mitochondria, the descendants of which in Brazil and the Caribbean still reflect their different regional African ancestries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBandelt, H. J., Alves-Silva, J., Guimaraes, P. E. M., Santos, M. S., Brehm, A., Pereira, L., ... & Torroni, A. (2001). Phylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave trade. Annals of human genetics, 65(6), 549-563.pt_PT
dc.identifier.doi10.1046/j.1469-1809.2001.6560549.xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3053
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherUniversity College Londonpt_PT
dc.relationESTUDO DE POLIMORFISMOS DO CROMOSSOMA Y E DO DNA MITOCONDRIAL NA POPULAÇÃO PORTUGUESA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhylogeographypt_PT
dc.subjectMitochondrial haplogroup L3ept_PT
dc.subjectAfrican pre-historypt_PT
dc.subjectAtlantic slave tradept_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titlePhylogeography of the human mitochondrial haplogroup L3e: a snapshot of African prehistory and Atlantic slave tradept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleESTUDO DE POLIMORFISMOS DO CROMOSSOMA Y E DO DNA MITOCONDRIAL NA POPULAÇÃO PORTUGUESA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PRAXIS XXI%2FBD%2F13632%2F97/PT
oaire.citation.endPage563pt_PT
oaire.citation.startPage549pt_PT
oaire.citation.titleAnnals of Human Geneticspt_PT
oaire.citation.volume65(6)pt_PT
person.familyNameBrehm
person.givenNameAntonio
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-idAuthor ID 7006085833
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery62d279e2-247a-4652-a370-3e8c2a846e31
relation.isProjectOfPublicationc2dcbc3d-eafa-40bc-bb90-2814faddb149
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