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Parental education and genetics of BMI from infancy to old age: a pooled analysis of 29 twin cohorts

2019Journal article Open access
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dc.contributor.authorSilventoinen, Karri
dc.contributor.authorJelenkovic, Aline
dc.contributor.authorLatvala, Antti
dc.contributor.authorYokoyama, Yoshie
dc.contributor.authorSund, Reijo
dc.contributor.authorSugawara, Masumi
dc.contributor.authorTanaka, Mami
dc.contributor.authorMatsumoto, Satoko
dc.contributor.authorAaltonen, Sari
dc.contributor.authorPiirtola, Maarit
dc.contributor.authorFreitas, Duarte L.
dc.contributor.authorMaia, José A.
dc.contributor.authorÖncel, Sevgi Y.
dc.contributor.authorAliev, Fazil
dc.contributor.authorJi, Fuling
dc.contributor.authorNing, Feng
dc.contributor.authorPang, Zengchang
dc.contributor.authorRebato, Esther
dc.contributor.authorSaudino, Kimberly J.
dc.contributor.authorCutler, Tessa L.
dc.contributor.authorHopper, John L.
dc.contributor.authorUllemar, Vilhelmina
dc.contributor.authorAlmqvist, Catarina
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorCozen, Wendy
dc.contributor.authorHwang, Amie E.
dc.contributor.authorMack, Thomas M.
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorBartels, Meike
dc.contributor.authorvan Beijsterveldt, Catharina E. M.
dc.contributor.authorNelson, Tracy L.
dc.contributor.authorWhitfield, Keith E.
dc.contributor.authorSung, Joohon
dc.contributor.authorKim, Jina
dc.contributor.authorLee, Jooyeon
dc.contributor.authorLee, Sooji
dc.contributor.authorLlewellyn, Clare H.
dc.contributor.authorFisher, Abigail
dc.contributor.authorMedda, Emanuela
dc.contributor.authorNisticò, Lorenza
dc.contributor.authorToccaceli, Virgilia
dc.contributor.authorBaker, Laura A.
dc.contributor.authorTuvblad, Catherine
dc.contributor.authorCorley, Robin P.
dc.contributor.authorHuibregtse, Brooke M.
dc.contributor.authorDerom, Catherine A.
dc.contributor.authorVlietinck, Robert F.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorKnafo‐Noam, Ariel
dc.contributor.authorMankuta, David
dc.contributor.authorAbramson, Lior
dc.contributor.authorBurt, S. Alexandra
dc.contributor.authorKlump, Kelly L.
dc.contributor.authorSilberg, Judy L.
dc.contributor.authorMaes, Hermine H.
dc.contributor.authorKrueger, Robert F.
dc.contributor.authorMcGue, Matt
dc.contributor.authorPahlen, Shandell
dc.contributor.authorGatz, Margaret
dc.contributor.authorButler, David A.
dc.contributor.authorHarris, Jennifer R.
dc.contributor.authorNilsen, Thomas S.
dc.contributor.authorHarden, K. Paige
dc.contributor.authorTucker‐Drob, Elliot M.
dc.contributor.authorFranz, Carol E.
dc.contributor.authorKremen, William S.
dc.contributor.authorLyons, Michael J.
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorJeong, Hoe‐Uk
dc.contributor.authorHur, Yoon‐Mi
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorSørensen, Thorkild I. A.
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2021-09-15T13:26:58Z
dc.date.available2021-09-15T13:26:58Z
dc.date.issued2019
dc.description.abstractObjective: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions. Methods: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling. Results: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia. Conclusions: Lower parental education level is associated with higher mean BMI and larger genetic vari ance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeco nomic differences in BMIpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilventoinen, K., Jelenkovic, A., Latvala, A., Yokoyama, Y., Sund, R., Sugawara, M., ... & Kaprio, J. (2019). Parental education and genetics of BMI from infancy to old age: a pooled analysis of 29 twin cohorts. Obesity, 27(5), 855-865. doi:10.1002/oby.22451pt_PT
dc.identifier.doi10.1002/oby.22451pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3631
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherObesity Societypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBMIpt_PT
dc.subjectGeneticspt_PT
dc.subjectParental educationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Sociaispt_PT
dc.titleParental education and genetics of BMI from infancy to old age: a pooled analysis of 29 twin cohortspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage865pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage855pt_PT
oaire.citation.titleObesitypt_PT
oaire.citation.volume27pt_PT
person.familyNameFreitas
person.familyNameKaprio
person.givenNameDuarte
person.givenNameJaakko
person.identifier.ciencia-idAA13-1821-A447
person.identifier.orcid0000-0001-6642-3370
person.identifier.orcid0000-0002-3716-2455
person.identifier.scopus-author-id37096975400
person.identifier.scopus-author-id35379599600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdfbe8c6f-691e-439f-b06e-832f0d8c1fa5
relation.isAuthorOfPublicationcda7cc68-24f8-49be-a0af-01f01b4f3475
relation.isAuthorOfPublication.latestForDiscoverydfbe8c6f-691e-439f-b06e-832f0d8c1fa5

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