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Unveiling potential functional applications of grape pomace extracts based on their phenolic profiling, bioactivities, and circular bioeconomy

2025-02-01Journal article Open access
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosCiências Naturais::Ciências Químicas
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
dc.contributor.authorAbreu, Teresa
dc.contributor.authorLuís, Catarina
dc.contributor.authorCâmara, José S.
dc.contributor.authorTeixeira, Juan
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorDe Abreu Abreu, Maria Teresa
dc.contributor.authorSousa Luís, Catarina Grace
dc.contributor.authorCâmara, José
dc.contributor.authorPerestrelo, Rosa
dc.date.accessioned2025-09-02T13:26:48Z
dc.date.available2025-09-02T13:26:48Z
dc.date.issued2025-02-01
dc.description.abstract<jats:title>Abstract</jats:title> <jats:p>Grape pomace (GP), a by-residue from the wine industry, contains bioactive molecules such as phenolic compounds, and anthocyanins, among others, with potential health benefits. In the current study, these bioactive molecules were extracted from GP of different <jats:italic>Vitis vinifera L.</jats:italic> varieties (Tinta Negra, Complexa, Malvasia Roxa, Malvasia, Sercial, Verdelho, Boal, Terrantez) using the micro quick, easy, cheap, effective, rugged, and safe (µQuEChERS) procedure. The GP extracts were investigated using ultra-high performance liquid chromatography (UHPLC-PDA) to establish the phenolic fingerprint, and by in vitro assays to assess the antibacterial, anti-inflammatory, and antioxidant activities. Nine phenolic compounds were identified and quantified in GP extracts, with gallic acid (ranging from 10.4 to 12.9 g/100 g), catechin (2.97 to 5.08 g/100 g), quercetin (2.17 to 2.85 g/100 g), and <jats:italic>trans</jats:italic>-resveratrol (0.28 to 1.82 g/100 g) being the most prominent. GP from the Complexa variety exhibited the highest levels of total anthocyanin content (TAC, 6.67 mgCGE/100 g), total phenolic compounds (TPC, 4727 mgGAE/100 g), and antioxidant activity (DPPH, 9472 mgTE/100 g), while the Tinta Negra variety had the highest total catechin content (TCC, 947 mgCATE/100 g). A strong correlation (<jats:italic>p</jats:italic> &lt; 0.001) was observed between the TPC-TAC, TPC-DPPH, DPPH-TAC, and TAC-TCC. Moreover, o-coumaric acid and quercetin are significantly (<jats:italic>p</jats:italic> &lt; 0.001) correlated with TPC, TAC, TCC, and DPPH assays. The investigated GP extracts, at a concentration of 100 µg/mL, showed promising inhibition of albumin protein denaturation compared to aspirin (reference standard). The findings showed that the GP extracts were more useful at inhibiting <jats:italic>Staphylococcus aureus</jats:italic> compared to <jats:italic>Escherichia coli</jats:italic>. It is important to emphasise that the GP extracts demonstrated antioxidant, anti-inflammatory, and antibacterial properties, positioning it as an agro-waste with promising potential for use in the development of innovative functional foods, dietary supplements, and cosmetics, aligning with the circular bioeconomy model for its valorisation.</jats:p>eng
dc.identifier.doi10.1007/s13399-025-06578-6
dc.identifier.issn2190-6815
dc.identifier.issn2190-6823
dc.identifier.urihttp://hdl.handle.net/10400.13/7363
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.relation.ispartofBiomass Conversion and Biorefinery
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGrape pomace
dc.subjectPhenolic fingerprint
dc.subjectµQuECHERS
dc.subjectUHPLC-PDA
dc.subjectCircular economy
dc.subjectValorisation
dc.subject.
dc.subjectCentro de Química da Madeira
dc.subjectFaculdade de Ciências da Vida
dc.subjectFaculdade de Ciências Exatas e da Engenharia
dc.titleUnveiling potential functional applications of grape pomace extracts based on their phenolic profiling, bioactivities, and circular bioeconomyeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDe Abreu Abreu
person.familyNameSousa Luís
person.familyNameCâmara
person.familyNamePerestrelo
person.givenNameMaria Teresa
person.givenNameCatarina Grace
person.givenNameJosé
person.givenNameRosa
person.identifierhttps://scholar.google.com/citations?hl=pt-BR&user=YT8V7XQAAAAJ
person.identifierC-1300-2019
person.identifierG-3003-2013
person.identifier1441319
person.identifier.ciencia-id8717-BA60-E569
person.identifier.ciencia-id9813-3B88-BA8D
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.ciencia-id251A-D5F7-9E32
person.identifier.orcid0000-0002-3018-3165
person.identifier.orcid0000-0003-1965-3151
person.identifier.orcid0000-0002-7223-1022
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id57194492726
person.identifier.scopus-author-id10140393000
person.identifier.scopus-author-id16686828800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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