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Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: key factor analysis (Part 2)

2019Journal article Restricted access
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dc.contributor.authorMignani, Serge
dc.contributor.authorRodrigues, João
dc.contributor.authorRoy, René
dc.contributor.authorShi, Xiangyang
dc.contributor.authorCeña, Valentin
dc.contributor.authorEl Kazzouli, Saïd
dc.contributor.authorMajoral, Jean-Pierre
dc.date.accessioned2019-06-28T11:08:09Z
dc.date.available2019-06-28T11:08:09Z
dc.date.issued2019
dc.description.abstractIn nanomedicine, the widespread concern of nanoparticles in general, and dendrimers, in particular, is the analysis of key in-vivo physicochemical parameters to ensure the preclinical and clinical development of 'safe' bioactive nanomaterials. It is clear that for biomedical applications, biocompatible dendrimers, used as nanocarriers or active per se, should be devoid of toxicity and immunogenicity, and have adequate PK/PD behaviors (adequate exposure) in order to diffuse in different tissues. Functionalization of dendrimers has a dramatic effect on in-vivo physicochemical parameters. In this review, we highlighted key in-vivo physicochemical properties, based on data from biochemical, cellular and animal models, to provide biocompatible dendrimers. Up-to-date, only scarce studies have been described on this topic.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMignani, S., Rodrigues, J., Roy, R., Shi, X., Ceña, V., El Kazzouli, S., & Majoral, J. P. (2019). Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2). Drug discovery today.pt_PT
dc.identifier.doi10.1016/j.drudis.2019.03.001pt_PT
dc.identifier.issn1359-6446
dc.identifier.urihttp://hdl.handle.net/10400.13/2443
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.subjectBiomedical dendrimerpt_PT
dc.subjectPhysicochemical parameterspt_PT
dc.subjectDendrimerspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleExploration of biomedical dendrimer space based on in-vivo physicochemical parameters: key factor analysis (Part 2)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.citation.endPage1192pt_PT
oaire.citation.startPage1184pt_PT
oaire.citation.titleDrug Discovery Todaypt_PT
oaire.citation.volume24(5)pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMignani
person.familyNameRodrigues
person.familyNameRoy
person.familyNameShi
person.familyNameCeña
person.givenNameSerge
person.givenNameJoão
person.givenNameRené
person.givenNameXiangyang
person.givenNameValentin
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-5638-7302
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0001-8928-3681
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.ridL-1751-2017
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7402953116
person.identifier.scopus-author-id56269211900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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