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MALDI-TOF MS: a promising analytical approach to cancer diagnostics and monitoring

2023-08-14Journal article Open access
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datacite.subject.fosCiências Médicas::Biotecnologia Médica
datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.fosCiências Naturais::Ciências Químicas
dc.contributor.authorSousa, Patrícia
dc.contributor.authorSilva, Laurentina
dc.contributor.authorLuís, Catarina
dc.contributor.authorCâmara, José S.
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorSousa Luís, Catarina Grace
dc.contributor.authorCâmara, José
dc.contributor.authorPerestrelo, Rosa
dc.date.accessioned2025-08-26T14:29:57Z
dc.date.available2025-08-26T14:29:57Z
dc.date.issued2023-08-14
dc.description.abstract<jats:p>Cancer remains the second most common cause of death after cardiovascular diseases, accounting for nearly 10 million deaths in 2020. Although the incidence of cancer increases considerably with age, the cancer burden can also be reduced and have a high chance of cure through early detection, appropriate treatment, and care of patients. The development of high-throughput analytical approaches, like matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), contributes to identifying a pool of proteins/peptides as putative biomarkers for the early detection, diagnosis, and tumor progression. The purpose of the current review is to present an updated outline of recent proteome/peptidome research to establish putative cancer biomarkers using MALDI-TOF MS and highlight the applicability of statistical analysis in the oncology field. The pros and cons of MALDI-TOF MS application on cancer diagnostics and monitoring will be discussed, as well as compared with tandem mass spectrometry (MS/MS)-based proteomics (e.g., liquid chromatography–tandem mass spectrometry). In addition, pre-analytical (e.g., sample quality control) and analytical (e.g., sample pre-treatment, instrumental analytical conditions) properties that influence the robustness of MALDI-TOF MS data will be also discussed.</jats:p>eng
dc.identifier.citationSousa, P.; Silva, L.; Luís, C.; Câmara, J.S.; Perestrelo, R. MALDI-TOF MS: A Promising Analytical Approach to Cancer Diagnostics and Monitoring. Separations 2023, 10, 453. https://doi.org/10.3390/ separations10080453
dc.identifier.doi10.3390/separations10080453
dc.identifier.issn2297-8739
dc.identifier.urihttp://hdl.handle.net/10400.13/7348
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.relation.ispartofSeparations
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer
dc.subjectProteome/peptidome
dc.subjectMALDI-TOF MS
dc.subjectSample pre-treatment
dc.subjectStatistical tool
dc.subjectBiomarkers
dc.subject.
dc.subjectCentro de Química da Madeira
dc.subjectFaculdade de Ciências Exatas e da Engenharia
dc.titleMALDI-TOF MS: a promising analytical approach to cancer diagnostics and monitoringeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue8
oaire.citation.titleSeparations
oaire.citation.volume10
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSousa Luís
person.familyNameCâmara
person.familyNamePerestrelo
person.givenNameCatarina Grace
person.givenNameJosé
person.givenNameRosa
person.identifierC-1300-2019
person.identifierG-3003-2013
person.identifier1441319
person.identifier.ciencia-id9813-3B88-BA8D
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.ciencia-id251A-D5F7-9E32
person.identifier.orcid0000-0002-3018-3165
person.identifier.orcid0000-0003-1965-3151
person.identifier.orcid0000-0002-7223-1022
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id57194492726
person.identifier.scopus-author-id10140393000
person.identifier.scopus-author-id16686828800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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