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Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death

2022Journal article Open access
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dc.contributor.authorPosadas, Inmaculada
dc.contributor.authorRomero-Castillo, Laura
dc.contributor.authorRonca, Rosa-Anna
dc.contributor.authorKarpus, Andrii
dc.contributor.authorMignani, Serge
dc.contributor.authorMajoral, Jean-Pierre
dc.contributor.authorMuñoz-Fernández, Mariángeles
dc.contributor.authorCeña, Valentin
dc.date.accessioned2024-02-29T16:16:41Z
dc.date.available2024-02-29T16:16:41Z
dc.date.issued2022
dc.description.abstractNanoparticles are playing an increasing role in biomedical applications. Excitotoxicity plays a significant role in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s or Parkinson’s disease. Glutamate ionotropic receptors, mainly those activated by N-methyl-D aspartate (NMDA), play a key role in excitotoxic death by increasing intraneuronal calcium levels; triggering mitochondrial potential collapse; increasing free radicals; activating caspases 3, 9, and 12; and inducing endoplasmic reticulum stress. Neutral phosphorous dendrimers, acting intracellularly, have neuroprotective actions by interfering with NMDA-mediated excitotoxic mechanisms in rat cortical neurons. In addition, phosphorous dendrimers can access neurons inside human brain organoids, complex tridimensional structures that replicate a significant number of properties of the human brain, to interfere with NMDA-induced mechanisms of neuronal death. Phosphorous dendrimers are one of the few nanoparticles able to gain access to the inside of neurons, both in primary cultures and in brain organoids, and to exert pharmacological actions by themselves.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRomero-Castillo, L.; Ronca, R.-A.; Karpus, A.; Mignani, S.; Majoral, J.-P.; Muñoz-Fernández, M.; Ceña, V. Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death. Int. J. Mol. Sci. 2022, 23, 4391. https://doi.org/ 10.3390/ijms23084391pt_PT
dc.identifier.doi10.3390/ijms23084391pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5594
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhosphorous dendrimerspt_PT
dc.subjectExcitotoxicitypt_PT
dc.subjectCortical neuronspt_PT
dc.subjectBrain organoidspt_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectMitochondriapt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleEngineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Deathpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue8pt_PT
oaire.citation.startPage4391pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRomero Castillo
person.familyNameMignani
person.familyNameMuñoz-Fernández
person.familyNameCeña
person.givenNameLaura
person.givenNameSerge
person.givenNameMª Ángeles
person.givenNameValentin
person.identifier548431
person.identifier.ciencia-id8018-B5D2-6983
person.identifier.ciencia-id361C-ABDD-87F4
person.identifier.orcid0000-0002-0271-212X
person.identifier.orcid0000-0002-1383-5256
person.identifier.orcid0000-0002-0813-4500
person.identifier.orcid0000-0001-8928-3681
person.identifier.ridL-1751-2017
person.identifier.scopus-author-id7003374430
person.identifier.scopus-author-id25931106800
person.identifier.scopus-author-id56269211900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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