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HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa

2005-04Journal article Restricted access
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dc.contributor.authorSpínola, H.
dc.contributor.authorMiddleton, D.
dc.contributor.authorBrehm, A.
dc.date.accessioned2018-11-09T15:24:04Z
dc.date.available2018-11-09T15:24:04Z
dc.date.issued2005-04
dc.description.abstractThe human leukocyte antigen-A (HLA-A), -B and -DRB1 polymorphism was examined in the Portuguese population, discriminating between North, Centre and South inhabitants. All data were obtained at high-resolution level, using sequence-based typing. The most frequent allele at each locus was A* 020101 (26%), B* 440301 and B* 510101 (12% each) and DRB1* 070101 (15%). The predominant three-locus haplotype was A*020101B*440301-DRB1*070101 (3.1%), highly frequent in North Portugal (5.4%), lower in Centre (2%) and absent in the South. The present study demonstrates that the Portuguese population has been genetically influenced by Europeans and North Africans, via several historic immigrations. North Portugal seems to concentrate, probably due to the pressure of Arab expansion, an ancient genetic pool originated from several North Africans and Europeans, influences throughout millenniums. South Portugal shows a North African genetic influence, probably of recent origin by means of Berbers accompanying Arab expansion. We found that Centre Portugal is the distribution limit of some alleles and haplotypes that characterize the North or the South of the country. Despite North, Centre and South Portugal not being significantly different in allele frequencies, this study shows that HLA allele and haplotype frequencies are not homogeneous in the country. North and South Portugal show more similarity to North Africans in opposition to Centre which appears closer to Europeans.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, H., Middleton, D., & Brehm, A. (2005). HLA genes in Portugal inferred from sequence‐based typing: in the crossroad between Europe and Africa. Tissue Antigens, 66(1), 26-36.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2150
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHLA-Apt_PT
dc.subjectHLA-Bpt_PT
dc.subjectHLA-DRB1pt_PT
dc.subjectHLA polymorphismpt_PT
dc.subjectHLA genespt_PT
dc.subjectPortugalpt_PT
dc.subjectÁfricapt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleHLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage36pt_PT
oaire.citation.startPage26pt_PT
oaire.citation.titleTissue Antigenspt_PT
oaire.citation.volume66(1)pt_PT
person.familyNameSpínola
person.familyNameBrehm
person.givenNameHélder
person.givenNameAntonio
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0002-6455-1595
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-id10242534600
person.identifier.scopus-author-idAuthor ID 7006085833
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ba0f1f6-73c8-46b2-b152-8cd3c90207ed
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication.latestForDiscovery1ba0f1f6-73c8-46b2-b152-8cd3c90207ed

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