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Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications

2012-03-21Journal article Restricted access
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dc.contributor.authorLi, Yulin
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.date.accessioned2019-06-19T14:12:46Z
dc.date.available2019-06-19T14:12:46Z
dc.date.issued2012-03-21
dc.description.abstractInjectable hydrogels with biodegradability have in situ formability which in vitro/in vivo allows an effective and homogeneous encapsulation of drugs/cells, and convenient in vivo surgical operation in a minimally invasive way, causing smaller scar size and less pain for patients. Therefore, they have found a variety of biomedical applications, such as drug delivery, cell encapsulation, and tissue engineering. This critical review systematically summarizes the recent progresses on biodegradable and injectable hydrogels fabricated from natural polymers (chitosan, hyaluronic acid, alginates, gelatin, heparin, chondroitin sulfate, etc.) and biodegradable synthetic polymers (polypeptides, polyesters, polyphosphazenes, etc.). The review includes the novel naturally based hydrogels with high potential for biomedical applications developed in the past five years which integrate the excellent biocompatibility of natural polymers/synthetic polypeptides with structural controllability via chemical modification. The gelation and biodegradation which are two key factors to affect the cell fate or drug delivery are highlighted. A brief outlook on the future of injectable and biodegradable hydrogels is also presented (326 references).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLi, Y., Rodrigues, J., & Tomas, H. (2012). Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chemical Society Reviews, 41(6), 2193-2221.pt_PT
dc.identifier.doi10.1039/c1cs15203cpt_PT
dc.identifier.issn0306-0012
dc.identifier.urihttp://hdl.handle.net/10400.13/2411
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationStrategic Project - UI 674 - 2011-2012
dc.subjectDrug delivery systemspt_PT
dc.subjectGelspt_PT
dc.subjectHydrogelspt_PT
dc.subjectBiomedical technologypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleInjectable and biodegradable hydrogels: gelation, biodegradation and biomedical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage2221pt_PT
oaire.citation.startPage2193pt_PT
oaire.citation.titleChemical Society Reviewspt_PT
oaire.citation.volume41(6)pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLi
person.familyNameRodrigues
person.familyNameTomás
person.givenNameYulin
person.givenNameJoão
person.givenNameHelena
person.identifier556975
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0001-5569-1038
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridA-4082-2013
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id55718977200
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationde21a0a9-a5a2-4521-b0e4-5902704f9bb0
relation.isAuthorOfPublication53031fca-b2e7-4ce4-bda9-61e486da4547
relation.isAuthorOfPublication3a747114-6ab9-454b-985b-00cbf792e273
relation.isAuthorOfPublication.latestForDiscovery3a747114-6ab9-454b-985b-00cbf792e273
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