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RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population

2008Journal article Open access
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dc.contributor.authorFreitas, Ana I.
dc.contributor.authorMendonça, Isabel
dc.contributor.authorBrión, Maria
dc.contributor.authorSequeira, Miguel M.
dc.contributor.authorReis, Roberto P.
dc.contributor.authorCarracedo, Angel
dc.contributor.authorBrehm, António
dc.date.accessioned2022-04-01T14:33:05Z
dc.date.available2022-04-01T14:33:05Z
dc.date.issued2008
dc.description.abstractBackground: Several polymorphisms within the renin-angiotensin system cluster of genes have been associated with the advent of coronary artery disease (CAD) or related pathologies. We investigated the distribution of 5 of these polymorphisms in order to find any association with CAD development and distinguish if any of the biochemical and behavioural factors interact with genetic polymorphisms in the advent of the disease. Methods: ACE I/D (rs4340), ACE A11860G (rs4343), AT1R A1166C (rs5186), AGT T174M (rs4762) and AGT M235T (rs699) gene polymorphisms were PCR-RFLP analysed in 298 CAD patients and 510 controls from Portugal. Several biochemical and behavioural markers were obtained. Results: ACE I/D DD and ACE11860 GG genotypes are risk factors for CAD in this population. The simultaneous presence of ACE I/D I and ACE11860 A alleles corresponds to a significant trend towards a decrease in CAD incidence. We found several synergistic effects between the studied polymorphisms and classical risk factors such as hypertension, obesity, diabetes and dyslipidaemia: the presence of the DD genotype of ACE I/D (and also ACE11860 GG) increases the odds of developing CAD when associated to each one of these classical risk factors, particularly when considering the male and early onset CAD subgroup analysis; AGT235 TT also increases the CAD risk in the presence of hypertension and dyslipidaemia, and AT1R1166 interacts positively with hypertension, smoking and obesity. Conclusion: ACE polymorphisms were shown to play a major role in individual susceptibility to develop CAD. There is also a clear interaction between RAS predisposing genes and some biochemical/environmental risk factors in CAD onset, demonstrating a significant enhancement of classical markers particularly by ACE I/D and ACE11860.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFreitas, A. I., Mendonça, I., Brión, M., Sequeira, M. M., Reis, R. P., Carracedo, A., & Brehm, A. (2008). RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population. BMC Cardiovascular Disorders, 8(1), 1-12.https://doi.org/10.1186/1471-2261-8-15pt_PT
dc.identifier.doi10.1186/1471-2261-8-15pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4217
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationPOLIMORFISMOS GENÉTICOS E RISCO DE DOENÇA CORONÁRIA NA MADEIRA. INTERACÇÃO COM OS MARCADORES DE RISCO CARDIOVASCULAR E O SEU PAPEL NO PROGNÓSTICO
dc.relationGenetic polymorphisms and risk of coronary heart disease in Madeira. Interaction with cardiovascular risk markers and their role in prognosis.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCoronary artery diseasept_PT
dc.subjectRAS gene polymorphismspt_PT
dc.subjectPortuguese populationpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleRAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePOLIMORFISMOS GENÉTICOS E RISCO DE DOENÇA CORONÁRIA NA MADEIRA. INTERACÇÃO COM OS MARCADORES DE RISCO CARDIOVASCULAR E O SEU PAPEL NO PROGNÓSTICO
oaire.awardTitleGenetic polymorphisms and risk of coronary heart disease in Madeira. Interaction with cardiovascular risk markers and their role in prognosis.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI-2010/SFRH%2FBD%2F8592%2F2002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FMGI%2F38697%2F2001/PT
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Cardiovascular Disorderspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStreamPOCI-2010
oaire.fundingStreamPOCI
person.familyNameCamacho de Freitas
person.familyNameSequeira
person.familyNameBrehm
person.givenNameAna Isabel
person.givenNameMiguel
person.givenNameAntonio
person.identifier.ciencia-id0E17-FBDF-CE9D
person.identifier.ciencia-idCA1C-1AC6-6346
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.orcid0000-0001-9728-465X
person.identifier.orcid0000-0003-3168-5340
person.identifier.scopus-author-id35101791200
person.identifier.scopus-author-idAuthor ID 7006085833
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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