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The use of chitosan oligosaccharide to improve artemisinin yield in well-watered and drought-stressed plants

2023Journal article Open access
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dc.contributor.authorGarcía-García, Ana L.
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorFeijão, Eduardo
dc.contributor.authorCarvalho, Ricardo Cruz de
dc.contributor.authorBoto, Alicia
dc.contributor.authorSilva, Jorge Marques da
dc.contributor.authorJiménez-Arias, David
dc.date.accessioned2023-10-27T15:07:52Z
dc.date.available2023-10-27T15:07:52Z
dc.date.issued2023
dc.description.abstractIntroduction: Artemisinin is a secondary metabolite well-known for its use in the treatment of malaria. It also displays other antimicrobial activities which further increase its interest. At present, Artemisia annua is the sole commercial source of the substance, and its production is limited, leading to a global deficit in supply. Furthermore, the cultivation of A. annua is being threatened by climate change. Specifically, drought stress is a major concern for plant development and productivity, but, on the other hand, moderate stress levels can elicit the production of secondary metabolites, with a putative synergistic interaction with elicitors such as chitosan oligosaccharides (COS). Therefore, the development of strategies to increase yield has prompted much interest. With this aim, the effects on artemisinin production under drought stress and treatment with COS, as well as physiological changes in A. annua plants are presented in this study. Methods: Plants were separated into two groups, well-watered (WW) and drought-stressed (DS) plants, and in each group, four concentrations of COS were applied (0, 50,100 and 200 mg•L-1). Afterwards, water stress was imposed by withholding irrigation for 9 days. Results: Therefore, when A. annua was well watered, COS did not improve plant growth, and the upregulation of antioxidant enzymes hindered the production of artemisinin. On the other hand, during drought stress, COS treatment did not alleviate the decline in growth at any concentration tested. However, higher doses improved the water status since leaf water potential (YL) improved by 50.64% and relative water content (RWC) by 33.84% compared to DS plants without COS treatment. Moreover, the combination of COS and drought stress caused damage to the plant’s antioxidant enzyme defence, particularly APX and GR, and reduced the amount of phenols and flavonoids. This resulted in increased ROS production and enhanced artemisinin content by 34.40% in DS plants treated with 200 mg•L-1 COS, compared to control plants. Conclusion: These findings underscore the critical role of ROS in artemisinin biosynthesis and suggest that COS treatment may boost artemisinin yield in crop production, even under drought conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGarcía-García AL, Matos AR, Feijão E, Carvalho R. Cruz de, Boto A, Silva, J. Marques da and Jiménez-Arias D (2023) The use of chitosan oligosaccharide to improve artemisinin yield in wellwatered and drought-stressed plants. Front. Plant Sci. 14:1200898. doi: 10.3389/fpls.2023.1200898pt_PT
dc.identifier.doi10.3389/fpls.2023.1200898pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5339
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationBiosystems and Integrative Sciences Institute
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChitosan oligosaccharidept_PT
dc.subjectArtemisininpt_PT
dc.subjectArtemisia annuapt_PT
dc.subjectDroughtpt_PT
dc.subjectElicitationpt_PT
dc.subjectStresspt_PT
dc.subjectBioactive metabolitespt_PT
dc.subject.pt_PT
dc.subjectCentro em Agricultura Sustentável e Tecnologia Alimentarpt_PT
dc.titleThe use of chitosan oligosaccharide to improve artemisinin yield in well-watered and drought-stressed plantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04046%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04046%2F2020/PT
oaire.citation.titleFrontiers in Plant Sciencept_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameJiménez-Arias
person.givenNameDavid
person.identifier182222
person.identifier.orcid0000-0003-2304-7373
person.identifier.scopus-author-id34880055200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryce020bf7-9b0f-4338-9a7b-83035239c306
relation.isProjectOfPublicationc086ae38-aeaf-404f-b202-273d51af3345
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