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The present and the future of degradable dendrimers and derivatives in theranostics

2015-07-15Journal article Restricted access
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dc.contributor.authorLeiro, Victoria
dc.contributor.authorGarcia, João Pedro
dc.contributor.authorTomás, Helena
dc.contributor.authorPêgo, Ana Paula
dc.date.accessioned2019-07-10T09:29:48Z
dc.date.available2019-07-10T09:29:48Z
dc.date.issued2015-07-15
dc.description.abstractInterest in dendrimer-based nanomedicines has been growing recently, as it is possible to precisely manipulate the molecular weight, chemical composition, and surface functionality of dendrimers, tuning their properties according to the desired biomedical application. However, one important concern about dendrimer-based therapeutics remains-the nondegradability under physiological conditions of the most commonly used dendrimers. Therefore, biodegradable dendrimers represent an attractive class of nanomaterials, since they present advantages over conventional nondegradable dendrimers regarding the release of the loaded molecules and the prevention of bioaccumulation of synthetic materials and subsequent cytotoxicity. Here, we present an overview of the state-of-the-art of the design of biodegradable dendritic structures, with particular focus on the hurdles regarding the use of these as vectors of drugs and nucleic acids, as well as macromolecular contrast agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLeiro, V., Garcia, J. P., Tomas, H., & Pego, A. P. (2015). The present and the future of degradable dendrimers and derivatives in theranostics. Bioconjugate chemistry, 26(7), 1182-1197.pt_PT
dc.identifier.doi10.1021/bc5006224pt_PT
dc.identifier.issn1043-1802
dc.identifier.urihttp://hdl.handle.net/10400.13/2472
dc.language.isoengpt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationStrategic Project - LA 2 - 2013-2014
dc.relationStrategic Project - UI 674 - 2014
dc.subjectDendrimerspt_PT
dc.subjectDegradable dendrimerspt_PT
dc.subjectDerivatives in theranosticspt_PT
dc.subjectTheranosticspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleThe present and the future of degradable dendrimers and derivatives in theranosticspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 2 - 2013-2014
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F112428%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FLA0002%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F69110%2F2010/PT
oaire.citation.endPage1197pt_PT
oaire.citation.startPage1182pt_PT
oaire.citation.titleBioconjugate Chemistrypt_PT
oaire.citation.volume26(7)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameLeiro
person.familyNameGarcia
person.familyNameTomás
person.familyNamePêgo
person.givenNameVictoria
person.givenNameJoão Pedro
person.givenNameHelena
person.givenNameAna Paula
person.identifier556975
person.identifier164495
person.identifier.ciencia-id7713-0BE4-AC65
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-id6114-92F0-E64C
person.identifier.orcid0000-0002-8907-9151
person.identifier.orcid0000-0002-4837-0401
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-5169-328X
person.identifier.ridK-1271-2013
person.identifier.ridE-5991-2010
person.identifier.ridC-6942-2012
person.identifier.scopus-author-id9634048000
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id56053889300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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