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HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands

2005-07Journal article Restricted access
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dc.contributor.authorSpínola, H.
dc.contributor.authorBrehm, A.
dc.contributor.authorBettencourt, B.
dc.contributor.authorMiddleton, D.
dc.contributor.authorBruges-Armas, J.
dc.date.accessioned2018-11-09T15:48:42Z
dc.date.available2018-11-09T15:48:42Z
dc.date.issued2005-07
dc.description.abstractHuman leucocyte antigen-A, -B, -Cw, -DRB1, -DQA1 and -DQB1 polymorphisms were examined in the Azorean population. The data were obtained at high-resolution level, using polymerase chain reaction (PCR) with sequence-specific primer, PCR-sequence-specific oligonucleotides and sequence-based typing. The most frequent allele in each locus was: A*0201 (24.5%), B*510101 (9.8%), Cw*0401 (14.8%), DRB1*070101 (18.3%), DQA1*0201 (17.4%) and DQB1*0301 (19.4%). The predominant extended haplotype was A*0202-B*1503-Cw*0202-DRB1*090102-DQA1*0303-DQB1*0202 (1.9%), which was found to be absent in the Portuguese mainland. The present study corroborates historical sources that say the Azores were populated not only by Portuguese but also by other Europeans, mostly Flemish people. Despite dendrogram analysis showing some remote Asian genetic affinities, the lack of specific alleles and haplotypes from those populations does not allow us to conclude for direct influence. Haplotype and allele frequencies in Azores show no homogeneous distribution between Oriental and Central islands of this archipelago. The Oriental islands harbour several haplotypes already found in mainland Portugal and identified as Mediterranean and European. The Central group of islands on the contrary clearly shows an influence of north Europeans (most probably derived from a well-documented Flemish settlement), with much less affinity to mainland Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSpínola, H., Brehm, A., Bettencourt, B., Middleton, D., & Bruges‐Armas, J. (2005). HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands. Tissue antigens, 66(3), 217-230.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2151
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHLA class Ipt_PT
dc.subjectHLA class IIpt_PT
dc.subjectHLA polymorphismpt_PT
dc.subjectAzores (Portugal)pt_PT
dc.subjectAçores (Portugal)pt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências da Vidapt_PT
dc.titleHLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islandspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage230pt_PT
oaire.citation.startPage217pt_PT
oaire.citation.titleTissue Antigenspt_PT
oaire.citation.volume66(3)pt_PT
person.familyNameSpínola
person.familyNameBrehm
person.familyNameArmas
person.givenNameHélder
person.givenNameAntonio
person.givenNameJacome
person.identifier682991
person.identifier.ciencia-id3613-8D1F-0EDF
person.identifier.ciencia-id8413-FBC3-5584
person.identifier.orcid0000-0002-6455-1595
person.identifier.orcid0000-0003-3168-5340
person.identifier.orcid0000-0001-7671-6521
person.identifier.scopus-author-id10242534600
person.identifier.scopus-author-idAuthor ID 7006085833
person.identifier.scopus-author-id55931428200
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ba0f1f6-73c8-46b2-b152-8cd3c90207ed
relation.isAuthorOfPublication62d279e2-247a-4652-a370-3e8c2a846e31
relation.isAuthorOfPublication887d1c55-c104-403c-b73e-acfa317c4e5d
relation.isAuthorOfPublication.latestForDiscovery887d1c55-c104-403c-b73e-acfa317c4e5d

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