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Fine tuning of the pH-sensitivity of laponite–doxorubicin nanohybrids by polyelectrolyte multilayer coating

2016Journal article Restricted access
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dc.contributor.authorXiao, Shili
dc.contributor.authorCastro, Rita
dc.contributor.authorMaciel, Dina
dc.contributor.authorGonçalves, Mara
dc.contributor.authorShi, Xiangyang
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.date.accessioned2019-06-25T09:02:53Z
dc.date.available2019-06-25T09:02:53Z
dc.date.issued2016
dc.description.abstractDespite the wide research done in the field, the development of advanced drug delivery systems with improved drug delivery properties and effective anticancer capability still remains a great challenge. Based on previous work that showed the potentialities of the nanoclay Laponite as a pH-sensitive doxorubicin (Dox) delivery vehicle, herein we report a simple method to modulate its extent of drug release at different pH values. This was achieved by alternate deposition of cationic poly(allylamine) hydrochloride and anionic poly(sodium styrene sulfonate) (PAH/PSS) polyelectrolytes over the surface of Dox-loaded Laponite nanoparticles using the electrostatic layer-by-layer (LbL) self-assembly approach. The successful formation of polyelectrolyte multilayer-coated Dox/Laponite systems was confirmed by Dynamic Light Scattering and zeta potential measurements. Systematic studies were performed to evaluate their drug release profiles and anticancer efficiency. Our results showed that the presence of the polyelectrolyte multilayers improved the sustained release properties of Laponite and allowed a fine tuning of the extension of drug release at neutral and acidic pH values. The cytotoxicity presented by polyelectrolyte multilayer-coated Dox/Laponite systems towards MCF-7 cells was in accordance with the drug delivery profiles. Furthermore, cellular uptake studies revealed that polyelectrolyte multilayer-coated Dox/Laponite nanoparticles can be effectively internalized by cells conducting to Dox accumulation in cell nucleus.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationXiao, S., Castro, R., Maciel, D., Gonçalves, M., Shi, X., Rodrigues, J., & Tomás, H. (2016). Fine tuning of the pH-sensitivity of laponite–doxorubicin nanohybrids by polyelectrolyte multilayer coating. Materials Science and Engineering: C, 60, 348-356.pt_PT
dc.identifier.doi10.1016/j.msec.2015.11.051pt_PT
dc.identifier.issn0928-4931
dc.identifier.urihttp://hdl.handle.net/10400.13/2426
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationNEW MATERIALS FOR BIOMEDICAL APPLICATIONS OBTAINED BY THE SELF-ASSEMBLY OF DENDRIMER-SINGLE STRANDED DNA CONJUGATES
dc.relationMadeira Chemistry Research Centre
dc.relationCONTROLLED ENZYMATIC ASSEMBLY OF SSDNA-FUNCTIONALIZED DENDRIMERS FOR BIOMEDICAL APPLICATIONS
dc.relationMetallodendrimers as HIV antiviral and anticancer agents.
dc.subjectLaponitept_PT
dc.subjectpH-sensitivity nanomaterialspt_PT
dc.subjectLayer-by-layer techniquept_PT
dc.subjectNanohybridpt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectAnticacer therapypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleFine tuning of the pH-sensitivity of laponite–doxorubicin nanohybrids by polyelectrolyte multilayer coatingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEW MATERIALS FOR BIOMEDICAL APPLICATIONS OBTAINED BY THE SELF-ASSEMBLY OF DENDRIMER-SINGLE STRANDED DNA CONJUGATES
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleCONTROLLED ENZYMATIC ASSEMBLY OF SSDNA-FUNCTIONALIZED DENDRIMERS FOR BIOMEDICAL APPLICATIONS
oaire.awardTitleMetallodendrimers as HIV antiviral and anticancer agents.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F75420%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00674%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F87465%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88721%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F102123%2F2014/PT
oaire.citation.endPage356pt_PT
oaire.citation.startPage348pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume60pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
oaire.fundingStreamOE
person.familyNameXiao
person.familyNameCastro
person.familyNameMaciel
person.familyNameGonçalves
person.familyNameShi
person.familyNameRodrigues
person.familyNameTomás
person.givenNameShili
person.givenNameRita
person.givenNameDina
person.givenNameMara
person.givenNameXiangyang
person.givenNameJoão
person.givenNameHelena
person.identifier556975
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person.identifier.ciencia-idBA11-1437-B948
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0001-9955-2064
person.identifier.orcid0000-0002-9337-062X
person.identifier.orcid0000-0001-8684-6100
person.identifier.orcid0000-0002-0332-3548
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.ridA-3537-2013
person.identifier.ridA-2497-2013
person.identifier.ridA-1289-2007
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.scopus-author-id35192467200
person.identifier.scopus-author-id54781586200
person.identifier.scopus-author-id55509603000
person.identifier.scopus-author-id7402953116
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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