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Polyethylenimine nanogels incorporated with ultrasmall iron oxide nanoparticles and doxorubicin for MR imaging-guided chemotherapy of tumors

2020Journal article Open access
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dc.contributor.authorZou, Yu
dc.contributor.authorLi, Du
dc.contributor.authorWang, Yue
dc.contributor.authorOuyang, Zhijun
dc.contributor.authorPeng, Yucheng
dc.contributor.authorTomás, Helena
dc.contributor.authorXia, Jindong
dc.contributor.authorRodrigues, João
dc.contributor.authorShen, Mingwu
dc.contributor.authorShi, Xiangyang
dc.date.accessioned2022-02-18T13:58:26Z
dc.date.available2022-02-18T13:58:26Z
dc.date.issued2020
dc.description.abstractDevelopment of versatile nanoplatforms for cancer theranostics remains a hot topic in the area of nanomedicine. We report here a general approach to create polyethylenimine (PEI)-based hybrid nanogels (NGs) incorporated with ultrasmall iron oxide (Fe3O4) nanoparticles (NPs) and doxorubicin for T1-weighted MR imaging guided chemotherapy of tumors. In this study, PEI NGs were first prepared using an inverse emulsion approach along with Michael addition reaction to cross-link the NGs, modified with citric acid stabilized ultrasmall Fe3O4 NPs through 1-ethyl-3-(3-(dimethylamino)- propyl) carbodiimide hydrochloride (EDC) coupling, and physically loaded with anticancer drug doxorubicin (DOX). The formed hybrid NGs possess good water dispersibility and colloidal stability, excellent DOX loading efficiency (51.4%), pH-dependent release profile of DOX with an accelerated release rate under acidic pH, and much higher r1 relaxivity (2.29 mM−1 s −1 ) than free ultrasmall Fe3O4 NPs (1.15 mM−1 s −1 ). In addition, in contrast to the drug-free NGs that possess good cytocompatibility, the DOX-loaded hybrid NGs display appreciable therapeutic activity and can be taken up by cancer cells in vitro. With these properties, the developed hybrid NGs enabled effective inhibition of tumor growth under the guidance of T1-weighted MR imaging. The developed hybrid NGs may be applied as a versatile nanoplatform for MR imaging-guided chemotherapy of tumors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZou, Y., Li, D., Wang, Y., Ouyang, Z., Peng, Y., Tomás, H., ... & Shi, X. (2020). Polyethylenimine nanogels incorporated with ultrasmall iron oxide nanoparticles and doxorubicin for MR imaging-guided chemotherapy of tumors. Bioconjugate Chemistry, 31(3), 907-915. https://doi.org/10.1021/acs.bioconjchem.0c00036pt_PT
dc.identifier.doi10.1021/acs.bioconjchem.0c00036pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/4093
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolyethylenimine nanogelspt_PT
dc.subjectUltrasmall iron oxide nanoparticlespt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectChemotherapy of tumorspt_PT
dc.subjectTumorspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titlePolyethylenimine nanogels incorporated with ultrasmall iron oxide nanoparticles and doxorubicin for MR imaging-guided chemotherapy of tumorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.endPage915pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage907pt_PT
oaire.citation.titleBioconjugate Chemistrypt_PT
oaire.citation.volume31pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameTomás
person.familyNameRodrigues
person.familyNameShi
person.givenNameHelena
person.givenNameJoão
person.givenNameXiangyang
person.identifier556975
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridE-5991-2010
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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