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Low generation triazine-based dendrimers-synthesis, characterzation and in vitro biological activity
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Authors
Abstract(s)
In the present study, two low generation triazine-based dendrimers, G1.0(Cl)4
dendrimer and G1.5(OH)8 dendrimer, were synthesized and their cytotoxicity were
tested by using the NIH 3T3 and the A2780 cell lines. In the synthesis process of the
G1.0(Cl)4 dendrimer, cyanuric chloride (CAC) which has high reactivity chlorine atom
was connected to the terminal of triethylene glycol (TEG) via nucleophilic substitution
by controlling temperature. The prepared G1.0(Cl)4 dendrimer was purified by silica
gel column chromatography. Then the four chlorine atoms in the G1.0(Cl)4 dendrimer
were substituted by diethanolamine (DEA) to give dendrimer with the hydroxyl
terminal group G1.5(OH)8.
The starting materials, CAC, G1.0(Cl)4 dendrimer and G1.5(OH)8 dendrimer
were analyzed by one-dimensional NMR, FTIR and MS techniques. The two
dendrimers, G1.0(Cl)4 and G1.5(OH)8, showed perfect stability in the air environment
at room temperature. However, G1.0(Cl)4 is not soluble in water while the G1.5(OH)8
dendrimer is a water soluble compound. Furthermore, cell biological evaluation at the
studied concentrations showed that the CAC, as well as the prepared G1.0(Cl)4 and
G1.5(OH)8 dendrimers, have no cytotoxicity towards the NIH 3T3 and A2780 cell
lines.
Description
Keywords
Química Nanoquímica Dendrimers Triazine-based Nanoestruturas Nanopartículas Química dos materiais Nanotecnologia Nanociências Técnicas in vitro Atividade biológica Triazines Cyanuric chloride Cytotoxicity Nanochemistry and Nanomaterials . Faculdade de Ciências Exatas e da Engenharia