Repository logo
 
Publication

Low generation triazine-based dendrimers-synthesis, characterzation and in vitro biological activity

2015-09Master thesis Open access
Simple item page
datacite.subject.fosCiências Naturais::Ciências Químicaspt_PT
datacite.subject.fosCiências Naturais::Ciências Biológicaspt_PT
dc.contributor.advisorRodrigues, João Manuel Cunha
dc.contributor.advisorTomás, Helena Maria Pires Gaspar
dc.contributor.authorZhang, Xupeng
dc.date.accessioned2016-06-02T13:57:12Z
dc.date.available2016-07-02T00:30:08Z
dc.date.issued2015-09
dc.description.abstractIn the present study, two low generation triazine-based dendrimers, G1.0(Cl)4 dendrimer and G1.5(OH)8 dendrimer, were synthesized and their cytotoxicity were tested by using the NIH 3T3 and the A2780 cell lines. In the synthesis process of the G1.0(Cl)4 dendrimer, cyanuric chloride (CAC) which has high reactivity chlorine atom was connected to the terminal of triethylene glycol (TEG) via nucleophilic substitution by controlling temperature. The prepared G1.0(Cl)4 dendrimer was purified by silica gel column chromatography. Then the four chlorine atoms in the G1.0(Cl)4 dendrimer were substituted by diethanolamine (DEA) to give dendrimer with the hydroxyl terminal group G1.5(OH)8. The starting materials, CAC, G1.0(Cl)4 dendrimer and G1.5(OH)8 dendrimer were analyzed by one-dimensional NMR, FTIR and MS techniques. The two dendrimers, G1.0(Cl)4 and G1.5(OH)8, showed perfect stability in the air environment at room temperature. However, G1.0(Cl)4 is not soluble in water while the G1.5(OH)8 dendrimer is a water soluble compound. Furthermore, cell biological evaluation at the studied concentrations showed that the CAC, as well as the prepared G1.0(Cl)4 and G1.5(OH)8 dendrimers, have no cytotoxicity towards the NIH 3T3 and A2780 cell lines.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/1179
dc.language.isoengpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.subjectQuímicapt_PT
dc.subjectNanoquímicapt_PT
dc.subjectDendrimerspt_PT
dc.subjectTriazine-basedpt_PT
dc.subjectNanoestruturaspt_PT
dc.subjectNanopartículaspt_PT
dc.subjectQuímica dos materiaispt_PT
dc.subjectNanotecnologiapt_PT
dc.subjectNanociênciaspt_PT
dc.subjectTécnicas in vitropt_PT
dc.subjectAtividade biológicapt_PT
dc.subjectTriazinespt_PT
dc.subjectCyanuric chloridept_PT
dc.subjectCytotoxicitypt_PT
dc.subjectNanochemistry and Nanomaterialspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleLow generation triazine-based dendrimers-synthesis, characterzation and in vitro biological activitypt_PT
dc.typemaster thesis
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typemasterThesispt_PT
relation.isProjectOfPublication75aaadc4-cd17-4fec-ba9d-1d0e564b3731
relation.isProjectOfPublication.latestForDiscovery75aaadc4-cd17-4fec-ba9d-1d0e564b3731
thesis.degree.nameDissertation submitted to the University of Madeira in fulfillment of the requirements for the degree of Master in Nanochemistry and Nanomaterialspt_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
MestradoXupeng Zhang.pdf
Size:
2.3 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Dissertações de Mestrado