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Antioxidant capacity, cytotoxicity and antimycobacterial activity of Madeira Archipelago endemic helichrysum dietary and medicinal plants

2014-10-31Journal article Open access
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dc.contributor.authorGouveia-Figueira, Sandra C.
dc.contributor.authorGouveia, Carla A.
dc.contributor.authorCarvalho, Maria J.
dc.contributor.authorRodrigues, Ana I.
dc.contributor.authorNording, Malin L.
dc.contributor.authorCastilho, Paula C.
dc.date.accessioned2021-03-30T13:27:58Z
dc.date.available2021-03-30T13:27:58Z
dc.date.issued2014-10-31
dc.description.abstractThe potential bioactivity of dietary and medicinal endemic Helichrysum plants from Madeira Archipelago was explored, for the first time, in order to supply new information for the general consumer. In vitro antioxidant properties were investigated using DPPH, ABTS(•+), FRAP and β-Carotene assays, and the total phenolic content (TPC) and total flavonoid content (TFC) were also determined. Although the results generally showed a large variation among the three analyzed plants, the methanolic extracts showed the highest antioxidant capacity. Exception is made for H. devium n-hexane extract that showed good radical scavenger capacity associated to compounds with good reducing properties. In the Artemia salina toxicity assay and antimycobaterial activity, H. devium was the most potent plant with the lowest LD50 at 216.7 ± 10.4 and MIC ≤ 50 μg·mL(-1). Chemometric evaluation (Principal Component Analysis-PCA) showed close interdependence between the ABTS, TPC and TFC methods and allowed to group H. devium samples.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGouveia-Figueira, S. C., Gouveia, C. A., Carvalho, M. J., Rodrigues, A. I., Nording, M. L., & Castilho, P. C. (2014). Antioxidant capacity, cytotoxicity and antimycobacterial activity of madeira archipelago endemic Helichrysum dietary and medicinal plants. Antioxidants, 3(4), 713-729.pt_PT
dc.identifier.doi10.3390/antiox3040713pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3225
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationISOLAMENTO E CARACTERIZAÇÃO DE PRINCÍPIOS ACTIVOS DE PLANTAS PARA O COMBATE À TUBERCULOSE
dc.relationStrategic Project - UI 674 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntimycobacterialpt_PT
dc.subjectArtemia salinapt_PT
dc.subjectHelichrysumpt_PT
dc.subjectChemometricspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleAntioxidant capacity, cytotoxicity and antimycobacterial activity of Madeira Archipelago endemic helichrysum dietary and medicinal plantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleISOLAMENTO E CARACTERIZAÇÃO DE PRINCÍPIOS ACTIVOS DE PLANTAS PARA O COMBATE À TUBERCULOSE
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F24227%2F2005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage729pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage713pt_PT
oaire.citation.titleAntioxidants (Basel, Switzerland)pt_PT
oaire.citation.volume3pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGouveia-Figueira
person.familyNameMenezes Carvalho
person.familyNameCastilho
person.givenNameSandra
person.givenNameMaria João
person.givenNamePaula C
person.identifierA-4412-2013
person.identifier.ciencia-id461A-2786-192D
person.identifier.ciencia-id6D15-8C69-A2E0
person.identifier.orcid0000-0002-8116-2794
person.identifier.orcid0000-0002-2769-276X
person.identifier.orcid0000-0002-8303-4286
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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