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Microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME) as sample preparation procedures for the metabolomic profiling of urine

2014-01-27Journal article Open access
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dc.contributor.authorLuís, Catarina
dc.contributor.authorCavaco, Carina
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorPereira, Jorge
dc.contributor.authorCâmara, José S.
dc.date.accessioned2019-05-23T10:22:44Z
dc.date.available2019-05-23T10:22:44Z
dc.date.issued2014-01-27
dc.description.abstractFor a long time, sample preparation was unrecognized as a critical issue in the analytical methodology, thus limiting the performance that could be achieved. However, the improvement of microextraction techniques, particularly microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), completely modified this scenario by introducing unprecedented control over this process. Urine is a biological fluid that is very interesting for metabolomics studies, allowing human health and disease characterization in a minimally invasive form. In this manuscript, we will critically review the most relevant and promising works in this field, highlighting how the metabolomic profiling of urine can be an extremely valuable tool for the early diagnosis of highly prevalent diseases, such as cardiovascular, oncologic and neurodegenerative ones.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, C., Cavaco, C., Perestrelo, R., Pereira, J., & Câmara, J. (2014). Microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME) as sample preparation procedures for the metabolomic profiling of urine. Metabolites, 4(1), 71-97.pt_PT
dc.identifier.doi10.3390/metabo4010071pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/2371
dc.language.isoengpt_PT
dc.publisherMDPIpt_PT
dc.relationStrategic Project - UI 674 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectUrinept_PT
dc.subjectMetabolomicspt_PT
dc.subjectMicroextraction by packed sorbentpt_PT
dc.subjectSolid-phase microextractionpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleMicroextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME) as sample preparation procedures for the metabolomic profiling of urinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/New-INDIGO%2F0003%2F2012/PT
oaire.citation.endPage97pt_PT
oaire.citation.startPage71pt_PT
oaire.citation.titleMetabolitespt_PT
oaire.citation.volume4(1)pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameSousa Luís
person.familyNamePerestrelo
person.familyNameAugusto Machado Pereira
person.familyNameCâmara
person.givenNameCatarina Grace
person.givenNameRosa
person.givenNameJorge
person.givenNameJosé
person.identifierC-1300-2019
person.identifier1441319
person.identifierG-3003-2013
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person.identifier.ciencia-idEC12-EE8F-50E8
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0002-3018-3165
person.identifier.orcid0000-0002-7223-1022
person.identifier.orcid0000-0003-0316-5348
person.identifier.orcid0000-0003-1965-3151
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id57194492726
person.identifier.scopus-author-id16686828800
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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