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Secondary bioactive metabolites from foods of plant origin as theravention agents against neurodegenerative disorders

2024-07-20Journal article Open access
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosCiências Naturais::Ciências Químicas
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
dc.contributor.authorGomes, Telma Marisa
dc.contributor.authorSousa, Patrícia
dc.contributor.authorCampos, Catarina
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorCâmara, José S.
dc.contributor.authorGomes, Telma
dc.contributor.authorPerestrelo, Rosa
dc.date.accessioned2025-09-01T14:50:51Z
dc.date.available2025-09-01T14:50:51Z
dc.date.issued2024-07-20
dc.description.abstract<jats:p>Neurodegenerative disorders (NDDs) such as Alzheimer’s (AD) and Parkinson’s (PD) are on the rise, robbing people of their memories and independence. While risk factors such as age and genetics play an important role, exciting studies suggest that a diet rich in foods from plant origin may offer a line of defense. These kinds of foods, namely fruits and vegetables, are packed with a plethora of powerful bioactive secondary metabolites (SBMs), including terpenoids, polyphenols, glucosinolates, phytosterols and capsaicinoids, which exhibit a wide range of biological activities including antioxidant, antidiabetic, antihypertensive, anti-Alzheimer’s, antiproliferative, and antimicrobial properties, associated with preventive effects in the development of chronic diseases mediated by oxidative stress such as type 2 diabetes mellitus, respiratory diseases, cancer, cardiovascular diseases, and NDDs. This review explores the potential of SBMs as theravention agents (metabolites with therapeutic and preventive action) against NDDs. By understanding the science behind plant-based prevention, we may be able to develop new strategies to promote brain health and prevent the rise in NDDs. The proposed review stands out by emphasizing the integration of multiple SBMs in plant-based foods and their potential in preventing NDDs. Previous research has often focused on individual compounds or specific foods, but this review aims to present a comprehensive fingerprint of how a diet rich in various SBMs can synergistically contribute to brain health. The risk factors related to NDD development and the diagnostic process, in addition to some examples of food-related products and medicinal plants that significantly reduce the inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), are highlighted.</jats:p>eng
dc.identifier.citationGomes, T.M.; Sousa, P.; Campos, C.; Perestrelo, R.; Câmara, J.S. Secondary Bioactive Metabolites from Foods of Plant Origin as Theravention Agents against Neurodegenerative Disorders. Foods 2024, 13, 2289. https://doi.org/ 10.3390/foods13142289
dc.identifier.doi10.3390/foods13142289
dc.identifier.issn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.13/7361
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMadeira Chemistry Research Centre
dc.relationMadeira Chemistry Research Centre
dc.relation.ispartofFoods
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPhytochemicals
dc.subjectSecondary bioactive metabolites
dc.subjectNeurodegenerative effects
dc.subjectAlzheimer’s disease
dc.subjectParkinson’s disease
dc.subjectTherapeutic and preventive strategies
dc.subject.
dc.subjectCentro de Química da Madeira
dc.subjectFaculdade de Ciências Exatas e da Engenharia
dc.titleSecondary bioactive metabolites from foods of plant origin as theravention agents against neurodegenerative disorderseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardTitleMadeira Chemistry Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00674%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00674%2F2020/PT
oaire.citation.issue14
oaire.citation.titleFoods
oaire.citation.volume13
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGomes
person.familyNamePerestrelo
person.givenNameTelma
person.givenNameRosa
person.identifier1441319
person.identifier.ciencia-id251A-D5F7-9E32
person.identifier.orcid0000-0002-9936-1142
person.identifier.orcid0000-0002-7223-1022
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id16686828800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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relation.isAuthorOfPublication.latestForDiscovery75c7755e-2373-40cf-9429-e5ac19cdf7d7
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