Repository logo
 
Publication

Attapulgite-doped electrospun poly(lactic-co-glycolic acid) nanofibers enable enhanced osteogenic differentiation of human mesenchymal stem cells

2015Journal article Open access
Simple item page
dc.contributor.authorWang, Zhe
dc.contributor.authorZhao, Yili
dc.contributor.authorLuo, Yu
dc.contributor.authorWang, Shige
dc.contributor.authorShen, Mingwu
dc.contributor.authorTomás, Helena
dc.contributor.authorZhu, Meifang
dc.contributor.authorShi, Xiangyang
dc.date.accessioned2019-07-10T08:58:23Z
dc.date.available2019-07-10T08:58:23Z
dc.date.issued2015
dc.description.abstractThe extracellular matrix mimicking property of electrospun polymer nanofibers affords their uses as an ideal scaffold material for differentiation of human mesenchymal stem cells (hMSCs), which is important for various tissue engineering applications. Here, we report the fabrication of electrospun poly(lactic-co-glycolic acid) (PLGA) nanofibers incorporated with attapulgite (ATT) nanorods, a clay material for osteogenic differentiation of hMSCs. We show that the incorporation of ATT nanorods does not significantly change the uniform morphology and the hemocompatibility of the PLGA nanofibers; instead the surface hydrophilicity and cytocompatibility of the hybrid nanofibers are slightly improved after doping with ATT. Alkaline phosphatase activity, osteocalcin secretion, calcium content, and von Kossa staining assays reveal that hMSCs are able to be differentiated to form osteoblast-like cells onto both PLGA and PLGA–ATT composite nanofibers in osteogenic medium. Most strikingly, the doped ATT within the PLGA nanofibers is able to induce the osteoblastic differentiation of hMSCs in growth medium without the inducing factor of dexamethasone. The fabricated organic/inorganic hybrid ATT-doped PLGA nanofibers may find many applications in the field of tissue engineering and regenerative medicine.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWang, Z., Zhao, Y., Luo, Y., Wang, S., Shen, M., Tomás, H., ... & Shi, X. (2015). Attapulgite-doped electrospun poly(lactic-co-glycolic acid) nanofibers enable enhanced osteogenic differentiation of human mesenchymal stem cells. RSC Advances, 5(4), 2383-2391.pt_PT
dc.identifier.doi10.1039/C4RA09839Kpt_PT
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/10400.13/2471
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationDENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors
dc.relationStrategic Project - UI 674 - 2011-2012
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHuman mesenchymal stem cells (hMSCs)pt_PT
dc.subjectElectrospun poly(lactic-co-10 glycolic acid) (PLGA) nanofiberspt_PT
dc.subjectAttapulgite-dopedpt_PT
dc.subjectHemocompatibility of the PLGA nanofiberspt_PT
dc.subjectHybrid nanofiberspt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleAttapulgite-doped electrospun poly(lactic-co-glycolic acid) nanofibers enable enhanced osteogenic differentiation of human mesenchymal stem cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F1748%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.citation.endPage2391pt_PT
oaire.citation.startPage2383pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume5(4)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameWang
person.familyNameTomás
person.familyNameShi
person.givenNameShige
person.givenNameHelena
person.givenNameXiangyang
person.identifier556975
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.ciencia-idBA11-1437-B948
person.identifier.orcid0000-0002-7639-6035
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-6785-6645
person.identifier.ridE-5991-2010
person.identifier.ridA-1289-2007
person.identifier.scopus-author-id53882129600
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id7402953116
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa6779e11-5b86-49a6-8731-8906fb680274
relation.isAuthorOfPublication3a747114-6ab9-454b-985b-00cbf792e273
relation.isAuthorOfPublicationc6b4b8c5-1241-4906-b4b9-ace5576b0b62
relation.isAuthorOfPublication.latestForDiscoveryc6b4b8c5-1241-4906-b4b9-ace5576b0b62
relation.isProjectOfPublication1b4615e9-8dd6-4eb3-8d2b-9b5afc12f590
relation.isProjectOfPublication595c1582-33c0-493a-8ab3-37d2811536d9
relation.isProjectOfPublication.latestForDiscovery1b4615e9-8dd6-4eb3-8d2b-9b5afc12f590

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Attapulgite-doped electrospun poly(lactic-co-glycolic acid) nanofibers enable enhanced osteogenic differentiation of human mesenchymal stem cells .pdf
Size:
3.26 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artigos em revistas internacionais