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Pharmacological and cosmeceutical potential of Seaweed Beach-Casts of Macaronesia

2020Journal article Open access
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dc.contributor.authorZárate, Rafael
dc.contributor.authorPortillo, Eduardo
dc.contributor.authorTeixidó, Sílvia
dc.contributor.authorCarvalho, Miguel A. A. Pinheiro de
dc.contributor.authorNunes, Nuno
dc.contributor.authorFerraz, Sónia
dc.contributor.authorSeca, Ana M. L.
dc.contributor.authorRosa, Gonçalo P.
dc.contributor.authorBarreto, Maria Carmo
dc.date.accessioned2021-11-22T09:45:40Z
dc.date.available2021-11-22T09:45:40Z
dc.date.issued2020
dc.description.abstractSeaweed beach-casts are a seasonal phenomenon that regularly deposits tons of algae biomass on beaches, which are usually disposed of in landfills. The present work aimed to contribute to the valorization of this biomass by studying bioactivities that reveal its potential in the pharmaceutical and/or cosmeceutical industries. Methanol and ethanol extracts and fractions from 15 beach-casts biomass were tested for a range of bioactivities. Eight of the most active samples exhibit IC50 values between 11.38 µg/mL and 19.28 µg/mL and selectivity indexes higher than 3.8, against NCI-H1299 (lung cancer) and T47D (breast cancer). Concerning antiaging potential, all the extracts tested presented UV protection, with SPF values above 30, like the standard sunscreen. Regarding aging-related enzymes, 24 samples were tyrosinase inhibitors exhibiting IC50 values from 9.01 µg/mL to 200.09 µg/mL. Eight extracts inhibited collagenase (IC50 < 248.76 µg/mL), two of them more actively than positive control EDTA (IC50 = 59.26 µg/mL). In addition to UV protection, the cumulative effect of antityrosinase and anticollagenase activities shown by the samples suggest that they may play a significant role in preventing skin photoaging. The results obtained demonstrate the high potential of beach-cast seaweed biomass as sources of cosmetic bioproducts with antiaging effects, and of selective cytotoxic metabolites.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZárate, R., Portillo, E., Teixidó, S., Carvalho, M. A., Nunes, N., Ferraz, S., ... & Barreto, M. C. (2020). Pharmacological and cosmeceutical potential of Seaweed Beach-Casts of Macaronesia. Applied Sciences, 10(17), 5831. https://doi.org/10.3390/app10175831pt_PT
dc.identifier.doi10.3390/app10175831pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3838
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for Ecology, Evolution and Environmental Changes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBeach-cast seaweedspt_PT
dc.subjectBiomass valorizationpt_PT
dc.subjectAnticancerpt_PT
dc.subjectAntiagingpt_PT
dc.subjectAntityrosinasept_PT
dc.subjectUV protectionpt_PT
dc.subject.pt_PT
dc.subjectEscola Superior de Tecnologias e Gestãopt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titlePharmacological and cosmeceutical potential of Seaweed Beach-Casts of Macaronesiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Ecology, Evolution and Environmental Changes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00329%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.citation.issue17pt_PT
oaire.citation.startPage5831pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlmeida Pinheiro de Carvalho
person.familyNameNunes
person.familyNameFerraz Alves
person.familyNameRoque Lino Felgueiras Barreto
person.givenNameMiguel Angelo
person.givenNameNuno
person.givenNameSónia
person.givenNameMaria do Carmo
person.identifier1218558
person.identifierN-8704-2015
person.identifier.ciencia-id4610-6741-6816
person.identifier.ciencia-idD412-34DB-BB84
person.identifier.ciencia-id3716-94D4-BF42
person.identifier.ciencia-idC512-A6FD-4A68
person.identifier.orcid0000-0002-5084-870X
person.identifier.orcid0000-0001-6166-8045
person.identifier.orcid0000-0001-7939-1371
person.identifier.orcid0000-0001-5797-8913
person.identifier.ridAEE-0913-2022
person.identifier.scopus-author-id8758577600
person.identifier.scopus-author-id7004455600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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