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Antitumor efficacy of doxorubicin-loaded laponite/alginate hybrid hydrogels

2014-01Journal article Restricted access
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dc.contributor.authorGonçalves, Mara
dc.contributor.authorFigueira, Priscilla
dc.contributor.authorMaciel, Dina
dc.contributor.authorRodrigues, João
dc.contributor.authorShi, Xiangyang
dc.contributor.authorTomás, Helena
dc.contributor.authorLi, Yulin
dc.date.accessioned2019-06-21T15:08:34Z
dc.date.available2019-06-21T15:08:34Z
dc.date.issued2014-01
dc.description.abstractDegradable hybrid hydrogels with improved stability are prepared by incorporating nanodisks of biocompatible laponite (LP) in alginate (AG) hydrogels using Ca2+ as a crosslinker. The Dox‐loaded hybrid hydrogels give a controlled Dox release at physiological environment in a sustained manner. Under conditions that mimic the tumor environment, both the sustainability in the Dox release (up to 17 d) and the release efficiency from LP/AG‐Dox hydrogels are improved. The in situ degradation of these hybrid hydrogels gives rise to nanohybrids that might serve as vehicles for carrying Dox through the cell membrane and diminish the effect of Dox ion‐trapping in the acidic extracellular environment of the tumor and/or in the endo‐lysosomal cell compartments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, M., Figueira, P., Maciel, D., Rodrigues, J., Shi, X., Tomás, H., & Li, Y. (2014). Antitumor efficacy of doxorubicin-loaded laponite/alginate hybrid hydrogels. Macromolecular bioscience, 14(1), 110-120.pt_PT
dc.identifier.doi10.1002/mabi.201300241pt_PT
dc.identifier.issn1616-5187
dc.identifier.urihttp://hdl.handle.net/10400.13/2420
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationStrategic Project - UI 674 - 2011-2012
dc.relationSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
dc.subjectAlginatespt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectBone neoplasmspt_PT
dc.subjectLaponitept_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectDrug stabilitypt_PT
dc.subjectGlucuronic acidpt_PT
dc.subjectHexuronic acidspt_PT
dc.subjectHydrogelspt_PT
dc.subjectOsteosarcomapt_PT
dc.subjectSilicatespt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleAntitumor efficacy of doxorubicin-loaded laponite/alginate hybrid hydrogelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardTitleSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F116788%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F112428%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88721%2F2012/PT
oaire.citation.endPage120pt_PT
oaire.citation.startPage110pt_PT
oaire.citation.titleMacromolecular Biosciencept_PT
oaire.citation.volume14(1)pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameGonçalves
person.familyNamePorto-Figueira
person.familyNameMaciel
person.familyNameRodrigues
person.familyNameShi
person.familyNameTomás
person.familyNameLi
person.givenNameMara
person.givenNamePriscilla
person.givenNameDina
person.givenNameJoão
person.givenNameXiangyang
person.givenNameHelena
person.givenNameYulin
person.identifier556975
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person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-idBA11-1437-B948
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0002-0332-3548
person.identifier.orcid0000-0001-7773-182X
person.identifier.orcid0000-0001-8684-6100
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-5569-1038
person.identifier.ridB-6816-2008
person.identifier.ridA-1289-2007
person.identifier.ridE-5991-2010
person.identifier.ridA-4082-2013
person.identifier.scopus-author-id55509603000
person.identifier.scopus-author-id56724173300
person.identifier.scopus-author-id54781586200
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id7402953116
person.identifier.scopus-author-id6508104177
person.identifier.scopus-author-id55718977200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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