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Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity

2013Journal article Restricted access
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dc.contributor.authorMaciel, Dina
dc.contributor.authorFigueira, Priscilla
dc.contributor.authorXiao, Shili
dc.contributor.authorHu, Dengmai
dc.contributor.authorShi, Xiangyang
dc.contributor.authorRodrigues, João
dc.contributor.authorTomás, Helena
dc.contributor.authorLi, Yulin
dc.date.accessioned2019-06-21T09:22:34Z
dc.date.available2019-06-21T09:22:34Z
dc.date.issued2013
dc.description.abstractAlthough doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is still a limitation. Herein, we report an easy process for the preparation of redox-sensitive nanogels that were shown to be highly efficient in the intracellular delivery of Dox. The nanogels (AG/Cys) were obtained through in situ cross-linking of alginate (AG) using cystamine (Cys) as a cross-linker via a miniemulsion method. Dox was loaded into the AG/Cys nanogels by simply mixing it in aqueous solution with the nanogels, that is, by the establishment of electrostatic interactions between the anionic AG and the cationic Dox. The results demonstrated that the AG/Cys nanogels are cytocompatible, have a high drug encapsulation efficiency (95.2 ± 4.7%), show an in vitro accelerated release of Dox in conditions that mimic the intracellular reductive conditions, and can quickly be taken up by CAL-72 cells (an osteosarcoma cell line), resulting in higher Dox intracellular accumulation and a remarkable cell death extension when compared with free Dox. The developed nanogels can be used as a tool to overcome the problem of Dox resistance in anticancer treatments and possibly be used for the delivery of other cationic drugs in applications beyond cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMaciel, D., Figueira, P., Xiao, S., Hu, D., Shi, X., Rodrigues, J., ... & Li, Y. (2013). Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity. Biomacromolecules, 14(9), 3140-3146.pt_PT
dc.identifier.doi10.1021/bm400768mpt_PT
dc.identifier.issn1525-7797
dc.identifier.urihttp://hdl.handle.net/10400.13/2414
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationStrategic Project - UI 674 - 2011-2012
dc.relationSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
dc.relationNEW MATERIALS FOR BIOMEDICAL APPLICATIONS OBTAINED BY THE SELF-ASSEMBLY OF DENDRIMER-SINGLE STRANDED DNA CONJUGATES
dc.subjectAbsorptionpt_PT
dc.subjectAlginatespt_PT
dc.subjectAntibiotics, Antineoplasticpt_PT
dc.subjectCell line, Tumorpt_PT
dc.subjectCell shapept_PT
dc.subjectCell survivalpt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectDrug carrierspt_PT
dc.subjectHumanspt_PT
dc.subjectKineticspt_PT
dc.subjectNanostructurespt_PT
dc.subjectOxidation-reductionpt_PT
dc.subjectSpectroscopy, Fourier Transform Infraredpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleRedox-responsive alginate nanogels with enhanced anticancer cytotoxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2011-2012
oaire.awardTitleSelf-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
oaire.awardTitleNEW MATERIALS FOR BIOMEDICAL APPLICATIONS OBTAINED BY THE SELF-ASSEMBLY OF DENDRIMER-SINGLE STRANDED DNA CONJUGATES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F116788%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-NAN%2F112428%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F75420%2F2010/PT
oaire.citation.endPage3146pt_PT
oaire.citation.startPage3140pt_PT
oaire.citation.titleBiomacromoleculespt_PT
oaire.citation.volume14(9)pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameMaciel
person.familyNamePorto-Figueira
person.familyNameXiao
person.familyNameShi
person.familyNameRodrigues
person.familyNameTomás
person.familyNameLi
person.givenNameDina
person.givenNamePriscilla
person.givenNameShili
person.givenNameXiangyang
person.givenNameJoão
person.givenNameHelena
person.givenNameYulin
person.identifier556975
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person.identifier.ciencia-idA81C-620E-DD6A
person.identifier.ciencia-id4D14-D31E-A8BE
person.identifier.orcid0000-0001-8684-6100
person.identifier.orcid0000-0001-7773-182X
person.identifier.orcid0000-0001-9955-2064
person.identifier.orcid0000-0001-6785-6645
person.identifier.orcid0000-0003-4552-1953
person.identifier.orcid0000-0002-7856-2041
person.identifier.orcid0000-0001-5569-1038
person.identifier.ridA-3537-2013
person.identifier.ridA-1289-2007
person.identifier.ridB-6816-2008
person.identifier.ridE-5991-2010
person.identifier.ridA-4082-2013
person.identifier.scopus-author-id54781586200
person.identifier.scopus-author-id56724173300
person.identifier.scopus-author-id35192467200
person.identifier.scopus-author-id7402953116
person.identifier.scopus-author-id9233278800
person.identifier.scopus-author-id6508104177
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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