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A critical time window for recovery extends beyond one-year post-stroke

2019Journal article Open access
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dc.contributor.authorBallester, Belén Rubio
dc.contributor.authorMaier, Martina
dc.contributor.authorDuff, Armin
dc.contributor.authorCameirão, Mónica
dc.contributor.authorBermúdez i Badia, Sergi
dc.contributor.authorDuarte, Esther
dc.contributor.authorCuxart, Ampar
dc.contributor.authorRodríguez, Susana
dc.contributor.authorSan Segundo Mozo, Rosa María
dc.contributor.authorVerschure, Paul F. M. J.
dc.date.accessioned2021-01-19T14:53:45Z
dc.date.available2021-01-19T14:53:45Z
dc.date.issued2019
dc.description.abstractThe impact of rehabilitation on post-stroke motor recovery and its dependency on the patient's chronicity remain unclear. The field has widely accepted the notion of a proportional recovery rule with a "critical window for recovery" within the first 3-6 mo poststroke. This hypothesis justifies the general cessation of physical therapy at chronic stages. However, the limits of this critical window have, so far, been poorly defined. In this analysis, we address this question, and we further explore the temporal structure of motor recovery using individual patient data from a homogeneous sample of 219 individuals with mild to moderate upper-limb hemiparesis. We observed that improvement in body function and structure was possible even at late chronic stages. A bootstrapping analysis revealed a gradient of enhanced sensitivity to treatment that extended beyond 12 mo poststroke. Clinical guidelines for rehabilitation should be revised in the context of this temporal structure. NEW & NOTEWORTHY Previous studies in humans suggest that there is a 3- to 6-mo "critical window" of heightened neuroplasticity poststroke. We analyze the temporal structure of recovery in patients with hemiparesis and uncover a precise gradient of enhanced sensitivity to treatment that expands far beyond the limits of the so-called critical window. These findings highlight the need for providing therapy to patients at the chronic and late chronic stages.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBallester, B. R., Maier, M., Duff, A., Cameirão, M., Bermúdez, S., Duarte, E., ... & Verschure, P. F. (2019). A critical time window for recovery extends beyond one-year post-stroke. Journal of neurophysiology, 122(1), 350-357.pt_PT
dc.identifier.doi10.1152/jn.00762.2018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3078
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Physiological Societypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAgedpt_PT
dc.subjectMiddle agedpt_PT
dc.subjectMovementpt_PT
dc.subjectNeuronal oplasticitypt_PT
dc.subjectParesispt_PT
dc.subjectStroke rehabilitationpt_PT
dc.subjectRecovery of functionpt_PT
dc.subjectNervous system pathophysiologypt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.titleA critical time window for recovery extends beyond one-year post-strokept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage357pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage350pt_PT
oaire.citation.titleJournal of Neurophysiologypt_PT
oaire.citation.volume122pt_PT
person.familyNameCameirão
person.familyNameBermúdez i Badia
person.givenNameMónica
person.givenNameSergi
person.identifier239789
person.identifier.ciencia-id0A12-4F21-0CC2
person.identifier.ciencia-idCA17-5E88-2B37
person.identifier.orcid0000-0002-5352-0128
person.identifier.orcid0000-0003-4452-0414
person.identifier.ridC-8675-2018
person.identifier.ridC-8681-2018
person.identifier.scopus-author-id21740694600
person.identifier.scopus-author-id6506360007
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication644f9f6a-81be-4b72-9ded-6eb1b8e251f4
relation.isAuthorOfPublicationef8f1e3b-3c09-4817-80d0-d96aa88051a2
relation.isAuthorOfPublication.latestForDiscovery644f9f6a-81be-4b72-9ded-6eb1b8e251f4

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