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Lipid biosignature of breast cancer tissues by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

2020Journal article Open access
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dc.contributor.authorSilva, Catarina L.
dc.contributor.authorPerestrelo, Rosa
dc.contributor.authorSousa-Ferreira, Ivo
dc.contributor.authorCapelinha, Filipa
dc.contributor.authorCâmara, José S.
dc.contributor.authorPetković, Marijana
dc.date.accessioned2022-01-04T16:27:13Z
dc.date.available2022-01-04T16:27:13Z
dc.date.issued2020
dc.description.abstractPurpose One of the hallmarks of cancer cells is the demand of supply for the synthesis of new membranes involved in cell proliferation and lipids have an important role in cellular structure, signaling pathways and progression of cancer. In this sense, lipid studies have become an essential tool allowing the establishment of signatures associated with breast cancer (BC). In this regard, some metabolic processes including proteins, nucleic acids and lipid synthesis are enhanced as part of cancer-associated metabolic reprogramming, as a requirement for cell growth and proliferation. Methods Pairwise samples of breast active carcinoma (BAC) and breast cancer-free tissues were collected from n=28 patients and analyzed by MALDI-TOF MS. Results Major lipid species are identifed in the MALDI-TOF mass spectra, with certain phosphatidylinositols (PIs) detect able only in BAC. Statistical analysis revealed signifcant diferences (p<0.05) between ratios lysophosphatidylcholine (LPC) 16:0/phosphatidylcholine (PC) 16:0_18:2 between AC and CF groups as well as for BC stages II and III. The ratio PC 16:0_18:2/PC16:0_18:1 was statistically diferent between AC and CF groups. The one-way ANOVA revealed that there are no statistical diferences among BC stages (I, II and III) within AC group. Comparing BC stages, the signifcance impact increased (p<0.05) with stage. Conclusion The obtained data revealed MALDI-TOF MS as a powerful tool to explore lipid signatures and the enzyme activity associated with BC and possibly establish novel disease markers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, C. L., Perestrelo, R., Sousa-Ferreira, I., Capelinha, F., Câmara, J. S., & Petković, M. (2020). Lipid biosignature of breast cancer tissues by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Breast cancer research and treatment, 182(1), 9-19. https://doi.org/10.1007/s10549-020-05672-9pt_PT
dc.identifier.doi10.1007/s10549-020-05672-9pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/3947
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationStrategic Project - UI 674 - 2014
dc.relationCentre of Statistics and its Applications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectTissuept_PT
dc.subjectLipidspt_PT
dc.subjectGlycerophosphocholinept_PT
dc.subjectMALDI-TOF MSpt_PT
dc.subject.pt_PT
dc.subjectFaculdade de Ciências Exatas e da Engenhariapt_PT
dc.subjectCentro de Química da Madeira
dc.titleLipid biosignature of breast cancer tissues by matrix-assisted laser desorption/ionization time-of-flight mass spectrometrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 674 - 2014
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0674%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAT%2F00006%2F2019/PT
oaire.citation.endPage19pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage9pt_PT
oaire.citation.titleBreast Cancer Research and Treatmentpt_PT
oaire.citation.volume182pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSousa Luís
person.familyNamePerestrelo
person.familyNameSousa Ferreira
person.familyNameCâmara
person.givenNameCatarina Grace
person.givenNameRosa
person.givenNameIvo Miguel
person.givenNameJosé
person.identifierC-1300-2019
person.identifier1441319
person.identifierG-3003-2013
person.identifier.ciencia-id9813-3B88-BA8D
person.identifier.ciencia-id251A-D5F7-9E32
person.identifier.ciencia-id6E10-F64C-8B54
person.identifier.ciencia-id481C-08CE-90E5
person.identifier.orcid0000-0002-3018-3165
person.identifier.orcid0000-0002-7223-1022
person.identifier.orcid0000-0001-5526-3594
person.identifier.orcid0000-0003-1965-3151
person.identifier.ridI-2307-2014
person.identifier.scopus-author-id57194492726
person.identifier.scopus-author-id16686828800
person.identifier.scopus-author-id57193736632
person.identifier.scopus-author-id10140393000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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