Repository logo
 
Publication

Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis

2007Journal article Open access
Simple item page
dc.contributor.authorChellappan, Sripriya
dc.contributor.authorKiran Kumar Reddy, G. S.
dc.contributor.authorAli, Akbar
dc.contributor.authorNalam, Madhavi N. L.
dc.contributor.authorAnjum, Saima Ghafoor
dc.contributor.authorCao, Hong
dc.contributor.authorKairys, Visvaldas
dc.contributor.authorFernandes, Miguel X.
dc.contributor.authorAltman, Michael D.
dc.contributor.authorTidor, Bruce
dc.contributor.authorRana, Tariq M.
dc.contributor.authorSchiffer, Celia A.
dc.contributor.authorGilson, Michael K.
dc.date.accessioned2023-02-07T10:35:46Z
dc.date.available2023-02-07T10:35:46Z
dc.date.issued2007
dc.description.abstractThere is a clinical need for HIV protease inhibitors that can evade resistance mutations. One possible approach to designing such inhibitors relies upon the crystallographic observation that the sub strates of HIV protease occupy a rather constant region within the binding site. In particular, it has been hypothesized that inhibitors which lie within this region will tend to resist clinically relevant mutations. The present study offers the first pros pective evaluation of this hypothesis, via compu tational design of inhibitors predicted to conform to the substrate envelope, followed by synthesis and evaluation against wild-type and mutant pro teases, as well as structural studies of complexes of the designed inhibitors with HIV protease. The results support the utility of the substrate envel ope hypothesis as a guide to the design of robust protease inhibitors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationhellappan, S., Kiran Kumar Reddy, G. S., Ali, A., Nalam, M. N., Anjum, S. G., Cao, H., ... & Gilson, M. K. (2007). Design of mutationā€resistant HIV protease inhibitors with the substrate envelope hypothesis. Chemical Biology & Drug Design, 69(5), 298-313.pt_PT
dc.identifier.doi10.1111/j.1747-0285.2007.00514.xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.13/5007
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAIDSpt_PT
dc.subjectCrystalpt_PT
dc.subjectDrug designpt_PT
dc.subjectInhibitorpt_PT
dc.subjectProteasept_PT
dc.subject.pt_PT
dc.subjectFaculdade de CiĆŖncias Exatas e da Engenhariapt_PT
dc.titleDesign of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage313pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage298pt_PT
oaire.citation.titleChemical Biology & Drug Designpt_PT
oaire.citation.volume69pt_PT
person.familyNameKairys
person.familyNameFernandes
person.givenNameVisvaldas
person.givenNameMiguel Xavier
person.identifierK-9893-2013
person.identifier.ciencia-idA716-F916-AFB2
person.identifier.ciencia-idED1D-3C7A-467C
person.identifier.orcid0000-0002-5427-0175
person.identifier.orcid0000-0002-1840-616X
person.identifier.ridA-4373-2013
person.identifier.scopus-author-id6602925161
person.identifier.scopus-author-id35466972500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication43821a45-10cf-4dbd-bc5a-fa88d146fc36
relation.isAuthorOfPublication8dab9a0d-f44a-4d2d-b9b1-7b3145162ca3
relation.isAuthorOfPublication.latestForDiscovery8dab9a0d-f44a-4d2d-b9b1-7b3145162ca3

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Design of mutationā€resistant HIV protease inhibitors with the substrate envelope hypothesis.pdf
Size:
1.48 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artigos em revistas internacionais